Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. - Wikidata - wikimedia - TriplyDB

Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display.

Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display.

http://www.wikidata.org/entity/Q31161442

about

Desmosomes in acquired disease Mechanistic basis of desmosome-targeted diseases Non-infectious environmental antigens as a trigger for the initiation of an autoimmune skin disease.Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies Translational applications of antibody phage display.Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus.Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapy Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence.Mechanisms of Autoantibody-Induced Pathology.Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus.Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies.Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blistering.Autoimmunity to desmocollin 3 in pemphigus vulgaris.Phage display--a powerful technique for immunotherapy: 1. Introduction and potential of therapeutic applications.p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris.Signaling dependent and independent mechanisms in pemphigus vulgaris blister formation Pemphigus vulgaris autoantibody profiling by proteomic technique.Desmoglein as a target in skin disease and beyond.Persistence of anti-desmoglein 3 IgG(+) B-cell clones in pemphigus patients over years.Autoimmune and infectious skin diseases that target desmogleins.Structure, function, and regulation of desmosomes.Pathogenic relevance of IgG and IgM antibodies against desmoglein 3 in blister formation in pemphigus vulgaris Nanorobotic investigation identifies novel visual, structural and functional correlates of autoimmune pathology in a blistering skin disease model.Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus.Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris.Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.Super-Resolution Microscopy Reveals Altered Desmosomal Protein Organization in Tissue from Patients with Pemphigus Vulgaris.Immunogenetics of pemphigus: an update.Desmoglein autoimmunity in the pathogenesis of pemphigus.Significance of autoimmunity to non-desmoglein targets in pemphigus.Pemphigus antibody induced phosphorylation of keratinocyte proteins.Pemphigus in the XXI century: new life to an old story.Enrichment of total serum IgG4 in patients with pemphigus The desmosome and pemphigus.The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases

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P2860

Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display.

http://www.wikidata.org/entity/Q31161442

description

2005 nî lūn-bûn

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2005 թվականի ապրիլին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Genetic and functional charact ...... ies isolated by phage display.

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Genetic and functional charact ...... ies isolated by phage display.

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Genetic and functional charact ...... ies isolated by phage display.

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Genetic and functional charact ...... ies isolated by phage display.

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Genetic and functional charact ...... ies isolated by phage display.

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Genetic and functional charact ...... ies isolated by phage display.

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Genetic and functional charact ...... ies isolated by phage display.

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Aimee S Payne

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Chenyan Lin

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Don L Siegel

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Hong Li

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John R Stanley

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Kazuyuki Tsunoda

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Ken Ishii

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Masayuki Amagai

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Stephen Kacir

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Yasushi Hanakawa

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P2860

Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome

Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal Toxin

Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris

Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1

Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation.

Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor.

Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: implications for Rh(D) epitope topology.

Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris.

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.

Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1.

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10.1172/JCI24185

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4

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