Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
about
Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical ScaffoldsInhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domainPlasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.Anti-inflammatory and Anti-arthritic Effects of a Novel Leflunomide Analogue, UTL-5b (GBL-5b).Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenaseConformational changes of the HsDHODH N-terminal Microdomain via DEER Spectroscopy.Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in miceIdentification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenaseEffect of hemodialysis on leflunomide plasma concentrations.Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.Hepatitis B virus reactivation in a juvenile rheumatoid arthritis patient under treatment and its successful management: a complicated case.Leflunomide-associated pancytopenia with or without methotrexate.Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition.A randomized trial of the prophylactic activity of DSM265 against pre-erythrocytic Plasmodium falciparum controlled human malaria infection by mosquito bites and direct venous inoculation.Mitochondrial dysfunction induced by leflunomide and its active metabolite.Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level.
P2860
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P2860
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
@ast
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
@en
type
label
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
@ast
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
@en
prefLabel
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
@ast
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
@en
P1476
Leflunomide, a novel immunomodulator for the treatment of active rheumatoid arthritis.
@en
P2093
Goldenberg MM
P304
1837-52; discussion 1821
P356
10.1016/S0149-2918(00)86732-6
P577
1999-11-01T00:00:00Z