The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.
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P1343
Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesisN-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-seGlycomic Approaches for the Discovery of Targets in Gastrointestinal CancerMass Spectrometry-Based N-Glycomics of Colorectal CancerControl of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene familyDeglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function.Evolutional and clinical implications of the epigenetic regulation of protein glycosylation.Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUC5AC mucin motif peptides.Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles.The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas.C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells.High-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes.Mucin glycosylation is altered by pro-inflammatory signaling in pancreatic-cancer cells.Glycosylation potential of human prostate cancer cell lines.Over-expression of ST3Gal-I promotes mammary tumorigenesis.Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines.The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer.Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen.Keratin 1 plays a critical role in golgi localization of core 2 N-acetylglucosaminyltransferase M via interaction with its cytoplasmic tail.Cancer vaccines and carbohydrate epitopes.Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.Cyclooxygenase-2 enzyme induces the expression of the α-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancerOnco-Golgi: Is Fragmentation a Gate to Cancer Progression?A non-enzymatic function of Golgi glycosyltransferases: mediation of Golgi fragmentation by interaction with non-muscle myosin IIAAberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma.CD45 glycosylation controls T-cell life and death.Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex.Analytical tools for the study of cellular glycosylation in the immune system.Altered tumor-cell glycosylation promotes metastasis.The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.Aberrant glycosylation as biomarker for cancer: focus on CD43.Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progressionMUC1 immunotherapy.The Tn antigen-structural simplicity and biological complexity.Golgi pH, its regulation and roles in human disease.Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology.Determination of the site-specific oligosaccharide distribution of the O-glycans attached to the porcine submaxillary mucin tandem repeat. Further evidence for the modulation of O-glycans side chain structures by peptide sequence.Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion.The effect of TNF-alpha on glycosylation pathways in bovine synoviocytes.Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer
P2860
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P2860
The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.
description
2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
The relative activities of the ...... or-associated epitope on MUC1.
@ast
The relative activities of the ...... or-associated epitope on MUC1.
@en
type
label
The relative activities of the ...... or-associated epitope on MUC1.
@ast
The relative activities of the ...... or-associated epitope on MUC1.
@en
prefLabel
The relative activities of the ...... or-associated epitope on MUC1.
@ast
The relative activities of the ...... or-associated epitope on MUC1.
@en
P2093
P2860
P356
P1476
The relative activities of the ...... or-associated epitope on MUC1.
@en
P2093
Brockhausen I
Burchell JM
Gschmeissner S
McFarlane I
Schwientek T
Taylor-Papadimitriou J
Whitehouse C
P2860
P304
11007-11015
P356
10.1074/JBC.M006523200
P407
P4510
P577
2000-12-15T00:00:00Z