Identification of the calmodulin-binding domain of recombinant calcium-independent phospholipase A2beta. implications for structure and function.
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Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionFcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cellsThe expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cellsPhospholipase A2 biochemistrySuperficial disposition of the N-terminal region of the surfactant protein SP-C and the absence of specific SP-B-SP-C interactions in phospholipid bilayersTwo chromogranin a-derived peptides induce calcium entry in human neutrophils by calmodulin-regulated calcium independent phospholipase A2Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cellsGenes encoding calmodulin-binding proteins in the Arabidopsis genome.Characterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests.Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcriptHighly selective hydrolysis of fatty acyl-CoAs by calcium-independent phospholipase A2beta. Enzyme autoacylation and acyl-CoA-mediated reversal of calmodulin inhibition of phospholipase A2 activity.Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonismDiabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils.Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling.Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA(2)β (VIA)-deficient mice.Activation mechanism for CRAC current and store-operated Ca2+ entry: calcium influx factor and Ca2+-independent phospholipase A2beta-mediated pathway.PLA2G6 mutation underlies infantile neuroaxonal dystrophyThe role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout miceGroup VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice.Mechanism-based inhibition of iPLA2β demonstrates a highly reactive cysteine residue (C651) that interacts with the active site: mass spectrometric elucidation of the mechanisms underlying inhibitionCalcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunctionSkeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation.Intracellular- and extracellular-derived Ca(2+) influence phospholipase A(2)-mediated fatty acid release from brain phospholipids.Regulation of taurine transport systems by protein kinase CK2 in mammalian cells.Smooth muscle cell arachidonic acid release, migration, and proliferation are markedly attenuated in mice null for calcium-independent phospholipase A2beta.Phospholipase A₂ activity in first episode schizophrenia: associations with symptom severity and outcome at week 12.Nitric oxide increases carbon monoxide production by piglet cerebral microvessels.PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.Arachidonic acid release mediated by OX1 orexin receptors.Regulation of taurine homeostasis by protein kinase CK2 in mouse fibroblasts.Prostaglandin synthesis in rat brain astrocytes is under the control of the n-3 docosahexaenoic acid, released by group VIB calcium-independent phospholipase A2.Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration.The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization.Orai, STIM1 and iPLA2beta: a view from a different perspective.
P2860
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P2860
Identification of the calmodulin-binding domain of recombinant calcium-independent phospholipase A2beta. implications for structure and function.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Identification of the calmodul ...... ns for structure and function.
@ast
Identification of the calmodul ...... ns for structure and function.
@en
type
label
Identification of the calmodul ...... ns for structure and function.
@ast
Identification of the calmodul ...... ns for structure and function.
@en
prefLabel
Identification of the calmodul ...... ns for structure and function.
@ast
Identification of the calmodul ...... ns for structure and function.
@en
P2093
P2860
P356
P1476
Identification of the calmodul ...... ns for structure and function.
@en
P2093
C M Jenkins
D J Mancuso
P2860
P304
P356
10.1074/JBC.M010439200
P407
P577
2000-12-15T00:00:00Z