Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control.
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Membrane microdomains emergence through non-homogeneous diffusion.Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic controlProminin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosisMolecular regulation of NKCC2 in the thick ascending limbPlant sterols as anticancer nutrients: evidence for their role in breast cancerDynamic association of human insulin receptor with lipid rafts in cells lacking caveolaeSeparation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functionsCholesterol depletion in adipocytes causes caveolae collapse concomitant with proteosomal degradation of cavin-2 in a switch-like fashionLipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation.Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathwaysTransient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides.Dynamin2, clathrin, and lipid rafts mediate endocytosis of the apical Na/K/2Cl cotransporter NKCC2 in thick ascending limbs.Physiopathological function of hematoside (GM3 ganglioside).Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes.Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol contentInsulin and insulin like growth factor II endocytosis and signaling via insulin receptor BLateral diffusion of cholesterol and dimyristoylphosphatidylcholine in a lipid bilayer measured by pulsed field gradient NMR spectroscopyCholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways.Lateral diffusion coefficients of separate lipid species in a ternary raft-forming bilayer: a Pfg-NMR multinuclear study.Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway.The Role of Caveolin 1 in HIV Infection and Pathogenesis.Changes in membrane cholesterol affect caveolin-1 localization and ICC-pacing in mouse jejunum.Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytesGlimepiride reduces the expression of PrPc, prevents PrPSc formation and protects against prion mediated neurotoxicity in cell lines.Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol.Impact of receptor clustering on ligand binding.IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.Lipid rafts are required for GLUT4 internalization in adipose cells.Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells.Lipid rafts play an important role for maintenance of embryonic stem cell self-renewal.Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms.Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys.Reducing plasma membrane sphingomyelin increases insulin sensitivity.The anti-diabetic bis(maltolato)oxovanadium(IV) decreases lipid order while increasing insulin receptor localization in membrane microdomains.Constitutive endocytosis and recycling of NKCC2 in rat thick ascending limbs.Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tetheringDynamics of plasma membrane microdomains and cross-talk to the insulin signalling cascade.Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.
P2860
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P2860
Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control.
description
2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Cholesterol depletion disrupts ...... ivated protein kinase control.
@ast
Cholesterol depletion disrupts ...... ivated protein kinase control.
@en
type
label
Cholesterol depletion disrupts ...... ivated protein kinase control.
@ast
Cholesterol depletion disrupts ...... ivated protein kinase control.
@en
prefLabel
Cholesterol depletion disrupts ...... ivated protein kinase control.
@ast
Cholesterol depletion disrupts ...... ivated protein kinase control.
@en
P2093
P356
P1476
Cholesterol depletion disrupts ...... ivated protein kinase control.
@en
P2093
P304
P356
10.1074/JBC.M007454200
P407
P577
2000-12-19T00:00:00Z