Confirmation of primary active substances from high throughput screening of chemical and biological populations: a statistical approach and practical considerations.
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A Comparison of Assay Performance Measures in Screening Assays: Signal Window, Z' Factor, and Assay Variability RatioIntegrating experimental and analytic approaches to improve data quality in genome-wide RNAi screensAntileishmanial high-throughput drug screening reveals drug candidates with new scaffoldsFunctional coupling of a nematode chemoreceptor to the yeast pheromone response pathwayHigh-throughput screening in primary neuronsPotential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri.Rank ordering plate data facilitates data visualization and normalization in high-throughput screeningEnrichment of extremely noisy high-throughput screening data using a naïve Bayes classifier.A simple strategy for mitigating the effect of data variability on the identification of active chemotypes from high-throughput screening data.Probing the primary screening efficiency by multiple replicate testing: a quantitative analysis of hit confirmation and false screening results of a biochemical assay.High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias.Evaluation of impermeant, DNA-binding dye fluorescence as a real-time readout of eukaryotic cell toxicity in a high throughput screening format.Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review.Systematic error detection in experimental high-throughput screening.Evaluation of a system to screen for stimulators of non-specific DNA nicking by HIV-1 integrase: application to a library of 50,000 compounds.1Click1View: interactive visualization methodology for RNAi cell-based microscopic screening.Identification of novel functionally selective κ-opioid receptor scaffolds.A new method with flexible and balanced control of false negatives and false positives for hit selection in RNA interference high-throughput screening assays.Assay strategies for identification of therapeutic leads that target protein traffickingPost-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.Non-stoichiometric inhibition in integrated lead finding - a literature review.Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.ChemBank: a small-molecule screening and cheminformatics resource databaseBioactivity and structure of biophenols as mediators of chronic diseases.On the prediction of statistical parameters in high-throughput screening using resampling techniques.Using clustering techniques to improve hit selection in high-throughput screening.An economic framework to prioritize confirmatory tests after a high-throughput screen.Development of a 1-microl scale assay for mitogen-activated kinase kinase 7 using 2-D fluorescence intensity distribution analysis anisotropy.NanoStore: a concept for logistical improvements of compound handling in high-throughput screening.Statistical analysis of systematic errors in high-throughput screening.
P2860
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P2860
Confirmation of primary active substances from high throughput screening of chemical and biological populations: a statistical approach and practical considerations.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Confirmation of primary active ...... and practical considerations.
@ast
Confirmation of primary active ...... and practical considerations.
@en
type
label
Confirmation of primary active ...... and practical considerations.
@ast
Confirmation of primary active ...... and practical considerations.
@en
prefLabel
Confirmation of primary active ...... and practical considerations.
@ast
Confirmation of primary active ...... and practical considerations.
@en
P2093
P356
P1476
Confirmation of primary active ...... and practical considerations.
@en
P2093
P304
P356
10.1021/CC9900706
P577
2000-05-01T00:00:00Z