Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.
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Development of bisphosphonates.Bisphosphonates: mechanism of action and role in clinical practiceOnce-yearly zoledronic acid in hip fracture preventionThe bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statinsActions of bisphosphonates in animal models of breast cancerHypercalcemia of malignancy and new treatment optionsHuman isoprenoid synthase enzymes as therapeutic targetsStructures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthasesMolecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium ParasitesDesign, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate SynthaseMedication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic ApproachesZoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells.Anti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines.Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme dataPotential antitumor effects of nitrogen-containing bisphosphonate in hormone receptor negative breast cancer patients with bone metastasesCombined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction.Early responsiveness of women with osteoporosis to teriparatide after therapy with alendronate or risedronateBisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk.The posttranslational processing of prelamin A and disease.Reduced osteoclastogenesis and RANKL expression in marrow from women taking alendronate.Efficacy and safety of zoledronic acid in the treatment of glucocorticoid-induced osteoporosis.Anti-Tumor Activity and Immunotherapeutic Potential of a Bisphosphonate Prodrug.How do bisphosphonates inhibit bone metastasis in vivo?Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis.Modifying the osteoblastic niche with zoledronic acid in vivo-potential implications for breast cancer bone metastasisThe impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro.Development of clinical utility of zoledronic acid and patient considerations in the treatment of osteoporosisBone disease in multiple myeloma: pathophysiology and management.Acute effects of intravenous administration of pamidronate in patients with osteoporosis.Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase.Bisphosphonates regulate cell proliferation, apoptosis and pro-osteoclastic expression in MG-63 human osteosarcoma cells.Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability.The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.Neonatal hypercalcemia secondary to subcutaneous fat necrosis successfully treated with pamidronate: a case series and literature reviewModeling the benefits of pamidronate in children with osteogenesis imperfecta.Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures.Bisphosphonates pathway.Role of zoledronic acid in the prevention and treatment of osteoporosis.Induction of creatine kinase release from cultured osteoclasts via the pharmacological action of aminobisphosphonates.Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.
P2860
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P2860
Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure-activity relationshi ...... en-containing bisphosphonates.
@ast
Structure-activity relationshi ...... en-containing bisphosphonates.
@en
type
label
Structure-activity relationshi ...... en-containing bisphosphonates.
@ast
Structure-activity relationshi ...... en-containing bisphosphonates.
@en
prefLabel
Structure-activity relationshi ...... en-containing bisphosphonates.
@ast
Structure-activity relationshi ...... en-containing bisphosphonates.
@en
P2093
P1476
Structure-activity relationshi ...... gen-containing bisphosphonates
@en
P2093
P304
P407
P577
2001-02-01T00:00:00Z