Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition.
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Mutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactionsRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersAutism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior.Assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na+ symporter family.Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.Trace amines inhibit insect odorant receptor function through antagonism of the co-receptor subunitModification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.Abuse liability profile of three substituted tryptamines.Early fluorescence signals detect transitions at mammalian serotonin transporters.Motoneuron excitability and muscle spasms are regulated by 5-HT2B and 5-HT2C receptor activity.Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transportA fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dotsMolecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation.Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter.Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies.Identification of novel serotonin transporter compounds by virtual screening.Natural and engineered coding variation in antidepressant-sensitive serotonin transporters.Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations.Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed.Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR.
P2860
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P2860
Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Interactions of tryptamine der ...... in I in substrate recognition.
@ast
Interactions of tryptamine der ...... in I in substrate recognition.
@en
type
label
Interactions of tryptamine der ...... in I in substrate recognition.
@ast
Interactions of tryptamine der ...... in I in substrate recognition.
@en
prefLabel
Interactions of tryptamine der ...... in I in substrate recognition.
@ast
Interactions of tryptamine der ...... in I in substrate recognition.
@en
P2093
P1476
Interactions of tryptamine der ...... in I in substrate recognition.
@en
P2093
P304
P577
2001-03-01T00:00:00Z