Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.
about
Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variabilityEvidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in manImproving integrative searching of systems chemical biology data using semantic annotationVariations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transportClinical application of transcriptional activators of bile salt transporters.Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicityGene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver.Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEPThiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discoverySpecies differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injurySystems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicityDiscovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytesNuclear receptors as drug targets in cholestatic liver diseases.Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes.Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats.Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP).Current concepts of mechanisms in drug-induced hepatotoxicity.MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells.Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice.
P2860
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P2860
Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Cholestatic potential of trogl ...... export pump (Bsep) in the rat.
@ast
Cholestatic potential of trogl ...... export pump (Bsep) in the rat.
@en
type
label
Cholestatic potential of trogl ...... export pump (Bsep) in the rat.
@ast
Cholestatic potential of trogl ...... export pump (Bsep) in the rat.
@en
prefLabel
Cholestatic potential of trogl ...... export pump (Bsep) in the rat.
@ast
Cholestatic potential of trogl ...... export pump (Bsep) in the rat.
@en
P2093
P1476
Cholestatic potential of trogl ...... export pump (Bsep) in the rat.
@en
P2093
P304
P577
2001-03-01T00:00:00Z