Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2.
about
Novel human secreted phospholipase A(2) with homology to the group III bee venom enzymePhospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionA substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathyVestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidaseMammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.Principles of calcite dissolution in human and artificial otoconiaOn the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymesOtolith tethering in the zebrafish otic vesicle requires Otogelin and α-TectorinSignatures from tissue-specific MPSS libraries identify transcripts preferentially expressed in the mouse inner ear.Gene targeting reveals the role of Oc90 as the essential organizer of the otoconial organic matrixOsteopontin is not critical for otoconia formation or balance function.Otoconin-90 deletion leads to imbalance but normal hearing: a comparison with other otoconia mutantsSource and role of endolymph macromolecules.Sequence variability, gene structure, and expression of full-length human endogenous retrovirus H.Inner ear proteomics of mouse models for deafness, a discovery strategy.ERV3 and related sequences in humans: structure and RNA expression.Matrix recruitment and calcium sequestration for spatial specific otoconia developmentCalcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation.In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structureOtopetrin 1 is required for otolith formation in the zebrafish Danio rerio.Regulation of cellular calcium in vestibular supporting cells by otopetrin 1Expression, functional, and structural analysis of proteins critical for otoconia developmentUnderstanding inner ear development with gene expression profiling.Effect of Otoconial Proteins Fetuin A, Osteopontin, and Otoconin 90 on the Nucleation and Growth of Calcite.A new era of secreted phospholipase A₂Mechanisms of otoconia and otolith developmentOtoconia and otolithic membrane fragments within the posterior semicircular canal in benign paroxysmal positional vertigo.Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial developmentDevelopment and evolution of the vestibular sensory apparatus of the mammalian ear.Immunogold TEM of otoconin 90 and otolin - relevance to mineralization of otoconia, and pathogenesis of benign positional vertigo.Sparc protein is required for normal growth of zebrafish otoliths.Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish.Proteomics studies in inner ear disorders: pathophysiology and biomarkers.Spatiotemporal differences in otoconial gene expression.Significance of tertiary conformation of otoconial matrix proteins - clinical implications.Formation of the inner ear during embryonic and larval development of the cichlid fish (Oreochromis mossambicus).Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti.Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1.Identification and characterization of mouse otic sensory lineage genes.
P2860
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P2860
Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Otoconin-90, the mammalian oto ...... to secretory phospholipase A2.
@ast
Otoconin-90, the mammalian oto ...... to secretory phospholipase A2.
@en
type
label
Otoconin-90, the mammalian oto ...... to secretory phospholipase A2.
@ast
Otoconin-90, the mammalian oto ...... to secretory phospholipase A2.
@en
prefLabel
Otoconin-90, the mammalian oto ...... to secretory phospholipase A2.
@ast
Otoconin-90, the mammalian oto ...... to secretory phospholipase A2.
@en
P2093
P2860
P356
P1476
Otoconin-90, the mammalian oto ...... to secretory phospholipase A2.
@en
P2093
P2860
P304
15345-15350
P356
10.1073/PNAS.95.26.15345
P407
P577
1998-12-01T00:00:00Z