Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy--a simulation study based on experimental data.
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How antipsychotics work-from receptors to reality.Cortical dopamine D2/D3 receptors are a common site of action for antipsychotic drugs--an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literatureHigh-affinity dopamine D2/D3 PET radioligands 18F-fallypride and 11C-FLB457: a comparison of kinetics in extrastriatal regions using a multiple-injection protocolDose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride.Calculating occupancy when one does not have baseline: a comparison of different optionsThe applicability of SRTM in [(18)F]fallypride PET investigations: impact of scan durations.Reference region modeling approaches for amphetamine challenge studies with [11C]FLB 457 and PETPredicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationshipQuantification of blood flow-dependent component in estimates of beta-amyloid load obtained using quasi-steady-state standardized uptake value ratio.The role of emission tomography in pharmacokinetic and pharmacodynamic studies in clinical psychopharmacology.[11C]cyclopropyl-FLB 457: a PET radioligand for low densities of dopamine D2 receptorsAntipsychotic occupancy of dopamine receptors in schizophrenia.Clozapine, atypical antipsychotics, and the benefits of fast-off D2 dopamine receptor antagonism.Therapeutic D2/3 receptor occupancies and response with low amisulpride blood concentrations in very late-onset schizophrenia-like psychosis (VLOSLP).Therapeutic window of dopamine D2/3 receptor occupancy to treat psychosis in Alzheimer's disease.Tactics for preclinical validation of receptor-binding radiotracers.Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain.Imaging of Dopamine in PD and Implications for Motor and Neuropsychiatric Manifestations of PD.The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole.Striatal and extrastriatal dopamine D₂ receptor occupancy by the partial agonist antipsychotic drug aripiprazole in the human brain: a positron emission tomography study with [¹¹C]raclopride and [¹¹C]FLB457.Age-related loss of extrastriatal dopamine D(2) -like receptors in women.Towards a therapeutic window of D2/3 occupancy for treatment of psychosis in Alzheimer's disease, with [18F]fallypride positron emission tomography.Extrastriatal dopamine D(2) receptor binding in Huntington's disease.Norepinephrine transporter occupancy in the human brain after oral administration of quetiapine XR.Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol.The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia.Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility.Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: re-evaluation of the validity of using a cerebellar reference region.In vivo quantification of striatal dopamine D2 receptor occupancy by JNJ-37822681 using [11C]raclopride and positron emission tomography.The relationship between dopamine receptor blockade and cognitive performance in schizophrenia: a [11C]-raclopride PET study with aripiprazole.In vivo quantification of neurofibrillary tangles with [F]MK-6240The use of healthy volunteers instead of patients to inform drug dosing studies: a [11C]raclopride PET study
P2860
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P2860
Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy--a simulation study based on experimental data.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Potentials and pitfalls using ...... dy based on experimental data.
@ast
Potentials and pitfalls using ...... dy based on experimental data.
@en
type
label
Potentials and pitfalls using ...... dy based on experimental data.
@ast
Potentials and pitfalls using ...... dy based on experimental data.
@en
prefLabel
Potentials and pitfalls using ...... dy based on experimental data.
@ast
Potentials and pitfalls using ...... dy based on experimental data.
@en
P356
P1433
P1476
Potentials and pitfalls using ...... dy based on experimental data.
@en
P2093
P304
P356
10.1006/NIMG.2001.0879
P407
P577
2001-10-01T00:00:00Z