Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.
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Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritisDrugs in development: bisphosphonates and metalloproteinase inhibitorsSerum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction.Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritisOsteoclast-independent bone resorption by fibroblast-like cellsBone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritisMechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications.A putative role for cathepsin K in degradation of AA and AL amyloidosisCathepsin K null mice show reduced adiposity during the rapid accumulation of fat storesThe final pathogenetic steps in focal bone erosions in rheumatoid arthritisAngiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorptionMMPs and rheumatoid synovial fibroblasts: Siamese twins in joint destruction?Bone destruction in arthritis.Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritisPivotal role of cathepsin K in lung fibrosis.Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand.Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium.Cells of the synovium in rheumatoid arthritis. OsteoclastsTRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.Honokiol possesses potential anti-inflammatory effects on rheumatoid arthritis and GM-CSF can be a target for its treatment.Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages.Proteinases in the joint: clinical relevance of proteinases in joint destructionJoint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation.Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis.Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10.Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritisCathepsin K Localizes to Equine Bone In Vivo and Inhibits Bone Marrow Stem and Progenitor Cells Differentiation In Vitro.Effect of a cathepsin K inhibitor on arthritis and bone mineral density in ovariectomized rats with collagen-induced arthritis.
P2860
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P2860
Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Cysteine proteinase cathepsin ...... of synovial bone destruction.
@ast
Cysteine proteinase cathepsin ...... of synovial bone destruction.
@en
type
label
Cysteine proteinase cathepsin ...... of synovial bone destruction.
@ast
Cysteine proteinase cathepsin ...... of synovial bone destruction.
@en
prefLabel
Cysteine proteinase cathepsin ...... of synovial bone destruction.
@ast
Cysteine proteinase cathepsin ...... of synovial bone destruction.
@en
P2093
P1476
Cysteine proteinase cathepsin ...... s of synovial bone destruction
@en
P2093
Müller-Ladner U
P304
P407
P577
1998-10-01T00:00:00Z