Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library.
about
Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental studyThe SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1.Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.Chemical genetics: ligand-based discovery of gene function.Inhibitor screening of proprotein convertases using positional scanning libraries.Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph.Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.Modulation of PC1/3 activity by self-interaction and substrate binding.Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.Inhibition of prohormone convertases PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives.The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.The extended granin family: structure, function, and biomedical implicationsMutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide.PCSK1 Variants and Human Obesity.The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.Mutations of the PC2 substrate binding pocket alter enzyme specificity.The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines.Altered neuropeptide processing in prefrontal cortex of Cpe (fat/fat) mice: implications for neuropeptide discovery.The C-terminal Region of proSAAS Is a Potent Inhibitor of Prohormone Convertase 1
P2860
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P2860
Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library.
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Identification of inhibitors o ...... peptide combinatorial library.
@ast
Identification of inhibitors o ...... peptide combinatorial library.
@en
type
label
Identification of inhibitors o ...... peptide combinatorial library.
@ast
Identification of inhibitors o ...... peptide combinatorial library.
@en
prefLabel
Identification of inhibitors o ...... peptide combinatorial library.
@ast
Identification of inhibitors o ...... peptide combinatorial library.
@en
P2093
P2860
P356
P1476
Identification of inhibitors o ...... peptide combinatorial library.
@en
P2093
E Apletalina
I Lindberg
N S Lamango
R A Houghten
P2860
P304
26589-26595
P356
10.1074/JBC.273.41.26589
P407
P577
1998-10-01T00:00:00Z