Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development.
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TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblastsBenzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 daysMice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors.Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment.DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient miceBenzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice.Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancerRole of nucleotide excision repair and p53 in zidovudine (AZT)-induced centrosomal deregulation.TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skinTopical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development.Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.miR-106a-mediated malignant transformation of cells induced by anti-benzo[a]pyrene-trans-7,8-diol-9,10-epoxide.Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats.Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA.Evaluation of the LacZ reporter assay in cryopreserved primary hepatocytes for In vitro genotoxicity testing.Proliferating primary hepatocytes from the pUR288 lacZ plasmid mouse are valuable tools for genotoxicity assessment in vitro
P2860
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P2860
Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development.
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Induction of DNA adducts and m ...... ation with tumour development.
@ast
Induction of DNA adducts and m ...... ation with tumour development.
@en
type
label
Induction of DNA adducts and m ...... ation with tumour development.
@ast
Induction of DNA adducts and m ...... ation with tumour development.
@en
prefLabel
Induction of DNA adducts and m ...... ation with tumour development.
@ast
Induction of DNA adducts and m ...... ation with tumour development.
@en
P2093
P356
P1433
P1476
Induction of DNA adducts and m ...... ation with tumour development.
@en
P2093
Broekhof JL
de Vries A
van Kreijl CF
van Steeg H
P304
P356
10.1093/CARCIN/18.12.2327
P407
P577
1997-12-01T00:00:00Z