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VE-PTP controls blood vessel development by balancing Tie-2 activitySH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeabilityB cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarityRegulation of developmental lymphangiogenesis by Syk(+) leukocytesShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesionFusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel FormationTargeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.Maturation of Platelet Function During Murine Fetal Development In Vivo.HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.Synergistic regulation of immunoreceptor signaling by SLP-76-related adaptor Clnk and serine/threonine protein kinase HPK-1.Signal transduction and co-stimulatory pathways.Identification of a clonally expanding haematopoietic compartment in bone marrowToxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapyA novel model for ectopic, chronic, intravital multiphoton imaging of bone marrow vasculature and architecture in split femurs.Modulation of synaptic function through the α-neurexin-specific ligand neurexophilin-1.The role of chemokines and their receptors in angiogenesis.Intravital two-photon microscopy of lymphatic vessel development and function using a transgenic Prox1 promoter-directed mOrange2 reporter mouse.Visualization of lymphatic vessel development, growth, and function.Receptor tyrosine kinase inhibitors: Are they real tumor killers?VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations.Statistical Permutation-based Artery Mapping (SPAM): a novel approach to evaluate imaging signals in the vessel wall.A qualitative comparison of ten tissue clearing techniques.The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis.The BAFFling function of Syk in B-cell homeostasis.Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors.Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.Cx47 fine-tunes the handling of serum lipids but is dispensable for lymphatic vascular function.A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level.Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development.Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases.Novel components of mammalian stress-activated protein kinase cascades.HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Friedemann Kiefer
@ast
Friedemann Kiefer
@en
Friedemann Kiefer
@es
Friedemann Kiefer
@sl
type
label
Friedemann Kiefer
@ast
Friedemann Kiefer
@en
Friedemann Kiefer
@es
Friedemann Kiefer
@sl
altLabel
F Kiefer
@en
prefLabel
Friedemann Kiefer
@ast
Friedemann Kiefer
@en
Friedemann Kiefer
@es
Friedemann Kiefer
@sl
P106
P1153
7006026974
P21
P31
P496
0000-0002-3002-8237