Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.
about
Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapyCompleting the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15.In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.Pretubulysin: a new option for the treatment of metastatic cancer.Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analoguesThe unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulationChemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing miceCyanobacterial peptides - nature's own combinatorial biosynthesis.Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis.Chemistry and biology of tubulysins: antimitotic tetrapeptides with activity against drug resistant cancers.Pseudomonas putida-a versatile host for the production of natural products.KtzJ-dependent serine activation and O-methylation by KtzH for kutznerides biosynthesis.Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2.The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells.Broad substrate specificity of ketoreductases derived from modular polyketide synthases.Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline.Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis.A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria.Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.Investigation of the biosynthesis of the pipecolate moiety of neuroprotective polyketide meridamycin.Structural and Functional Trends in Dehydrating Bimodules from trans-Acyltransferase Polyketide Synthases.
P2860
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P2860
Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity.
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Identification and analysis of ...... potential anticancer activity.
@ast
Identification and analysis of ...... potential anticancer activity.
@en
type
label
Identification and analysis of ...... potential anticancer activity.
@ast
Identification and analysis of ...... potential anticancer activity.
@en
prefLabel
Identification and analysis of ...... potential anticancer activity.
@ast
Identification and analysis of ...... potential anticancer activity.
@en
P1476
Identification and analysis of ...... potential anticancer activity
@en
P2093
Axel Sandmann
Florenz Sasse
P304
P356
10.1016/J.CHEMBIOL.2004.05.014
P50
P577
2004-08-01T00:00:00Z