Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.

Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.

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http://www.wikidata.org/entity/Q33210643
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal developmentThe diphthamide modification pathway from Saccharomyces cerevisiae--revisitedThe amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction networkLoss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factorUse of forward genetics to discover novel regulators of NF-kappaB.Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNALysUUU modifications.Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADPRibosylating Toxins.Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome.Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types.Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stressImportance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast
P2860

Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.

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http://www.wikidata.org/entity/Q33210643
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2005 nî lūn-bûn
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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2005 թվականի հունվարին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年论文
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Gene trap mutagenesis-based fo ...... hamide on elongation factor 2.
@ast
Gene trap mutagenesis-based fo ...... hamide on elongation factor 2.
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type
label
Gene trap mutagenesis-based fo ...... hamide on elongation factor 2.
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Gene trap mutagenesis-based fo ...... hamide on elongation factor 2.
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Gene trap mutagenesis-based fo ...... hamide on elongation factor 2.
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Gene trap mutagenesis-based fo ...... hamide on elongation factor 2.
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P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Gene trap mutagenesis-based fo ...... hamide on elongation factor 2.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698