about
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitorsDiscovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking ApproachInside the mind of a medicinal chemist: the role of human bias in compound prioritization during drug discoveryAdvances in Nuclear Magnetic Resonance for Drug Discovery.Screening library evolution through automation of solution preparation.Screening of small molecule interactor library by using in-cell NMR spectroscopy (SMILI-NMR).The STINT-NMR method for studying in-cell protein-protein interactions.Experimental validation of a fragment library for lead discovery using SPR biosensor technology.The design of novel inhibitors for treating cancer by targeting CDC25B through disruption of CDC25B-CDK2/Cyclin A interaction using computational approaches.Recent trends and observations in the design of high-quality screening collections.Targeting metalloproteins by fragment-based lead discovery.Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics.Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.A reverse combination of structure-based and ligand-based strategies for virtual screening.Protein crystallography and fragment-based drug design.Therapeutic approaches to preventing cell death in Huntington diseaseIn situ click chemistry: a powerful means for lead discovery.Fragment-based approaches to enzyme inhibitionEvolutions in fragment-based drug design: the deconstruction-reconstruction approachThe importance of molecular complexity in the design of screening libraries.A three-stage biophysical screening cascade for fragment-based drug discovery.A fluorescent approach for identifying P2X1 ligandsTargeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists.Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.Emerging challenges in ligand discovery: new opportunities for chromatographic assay.Inhibition of prenylated KRAS in a lipid environmentIntegrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5.Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease.A decade of fragment-based drug design: strategic advances and lessons learned.Computational medicinal chemistry in fragment-based drug discovery: what, how and when.Fragment informatics and computational fragment-based drug design: an overview and update.When analoging is not enough: scaffold discovery in medicinal chemistry.In silico fragment-based drug design.Fragment-based drug discovery using the SHAPES method.Computer applications for prediction of protein-protein interactions and rational drug design.Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12.An in vitro assay to measure targeted drug delivery to bone mineral.A structural biology view of target drugability.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Library design for fragment based screening.
@ast
Library design for fragment based screening.
@en
type
label
Library design for fragment based screening.
@ast
Library design for fragment based screening.
@en
prefLabel
Library design for fragment based screening.
@ast
Library design for fragment based screening.
@en
P2093
P356
P1476
Library design for fragment based screening.
@en
P2093
Andreas L Marzinzik
Ansgar Schuffenhauer
Edgar Jacoby
Marcel Blommers
Paul Selzer
Simon Ruedisser
Wolfgang Jahnke
P304
P356
10.2174/1568026054637700
P577
2005-01-01T00:00:00Z