Determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates.
about
AAV gene transfer delays disease onset in a TPP1-deficient canine model of the late infantile form of Batten disease.Structure of tripeptidyl-peptidase I provides insight into the molecular basis of late infantile neuronal ceroid lipofuscinosisCrystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid LipofuscinosisInteractions of the proteins of neuronal ceroid lipofuscinosis: clues to functionA critical tryptophan and Ca2+ in activation and catalysis of TPPI, the enzyme deficient in classic late-infantile neuronal ceroid lipofuscinosisUsing specificity to strategically target proteases.A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies.Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material.Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.Tripeptidyl-peptidase I in health and disease.Residual levels of tripeptidyl-peptidase I activity dramatically ameliorate disease in late-infantile neuronal ceroid lipofuscinosis.Intravitreal Implantation of Genetically Modified Autologous Bone Marrow-Derived Stem Cells for Treating Retinal Disorders.A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium.Tandem mass spectrometry assays of palmitoyl protein thioesterase 1 and tripeptidyl peptidase activity in dried blood spots for the detection of neuronal ceroid lipofuscinoses in newborns.Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain.Overcoming Limitations Inherent in Sulfamidase to Improve Mucopolysaccharidosis IIIA Gene Therapy.Multiplex Tandem Mass Spectrometry Enzymatic Activity Assay for Newborn Screening of the Mucopolysaccharidoses and Type 2 Neuronal Ceroid Lipofuscinosis.Detection of tripeptidyl peptidase I activity in living cells by fluorogenic substrates.
P2860
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P2860
Determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Determination of the substrate ...... proved fluorogenic substrates.
@ast
Determination of the substrate ...... proved fluorogenic substrates.
@en
type
label
Determination of the substrate ...... proved fluorogenic substrates.
@ast
Determination of the substrate ...... proved fluorogenic substrates.
@en
prefLabel
Determination of the substrate ...... proved fluorogenic substrates.
@ast
Determination of the substrate ...... proved fluorogenic substrates.
@en
P2093
P2860
P356
P1476
Determination of the substrate ...... proved fluorogenic substrates.
@en
P2093
Istvan Sohar
John W Taylor
Peter Lobel
P2860
P304
P356
10.1074/JBC.M507336200
P407
P577
2005-12-08T00:00:00Z