Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.
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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patternsCooperative epigenetic modulation by cancer amplicon genesThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerJAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsIntegrating non-coding RNAs in JAK-STAT regulatory networksSOCS, inflammation, and cancerThe role of suppressors of cytokine signalling in human neoplasmsIdentification of predictive pathways for non-hodgkin lymphoma prognosisThe class-I HDAC inhibitor MGCD0103 induces apoptosis in Hodgkin lymphoma cell lines and synergizes with proteasome inhibitors by an HDAC6-independent mechanism.Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.Pathobiology of hodgkin lymphoma.Lestaurtinib inhibition of the Jak/STAT signaling pathway in hodgkin lymphoma inhibits proliferation and induces apoptosisSB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.FOXO1 downregulation contributes to the oncogenic program of primary mediastinal B-cell lymphoma.MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1The molecular pathogenesis of Hodgkin lymphoma.Phase I study of a novel oral Janus kinase 2 inhibitor, SB1518, in patients with relapsed lymphoma: evidence of clinical and biologic activity in multiple lymphoma subtypes.Hodgkin lymphoma.Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib.Subclonal evolution of a classical Hodgkin lymphoma from a germinal center B-cell-derived mantle cell lymphoma.Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignanciesMutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphomaSuppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma.Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines.Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy.A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.Recurrent somatic loss of TNFRSF14 in classical Hodgkin lymphoma.The role of Janus kinases in haemopoiesis and haematological malignancy.Hodgkin's lymphoma: molecular targets and novel treatment strategies.IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesisThe molecular biology of diffuse large B-cell lymphoma.SOCS1 mutation subtypes predict divergent outcomes in diffuse large B-Cell lymphoma (DLBCL) patients.Recent insights into the biology of Hodgkin lymphoma: unraveling the mysteries of the Reed-Sternberg cell.MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.Commentary on the WHO classification of tumors of lymphoid tissues (2008): "Gray zone" lymphomas overlapping with Burkitt lymphoma or classical Hodgkin lymphoma.Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment.Molecular pathways: molecular basis for sensitivity and resistance to JAK kinase inhibitors.Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.
P2860
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P2860
Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Mutations of the tumor suppres ...... ar phospho-STAT5 accumulation.
@ast
Mutations of the tumor suppres ...... ar phospho-STAT5 accumulation.
@en
type
label
Mutations of the tumor suppres ...... ar phospho-STAT5 accumulation.
@ast
Mutations of the tumor suppres ...... ar phospho-STAT5 accumulation.
@en
prefLabel
Mutations of the tumor suppres ...... ar phospho-STAT5 accumulation.
@ast
Mutations of the tumor suppres ...... ar phospho-STAT5 accumulation.
@en
P2093
P356
P1433
P1476
Mutations of the tumor suppres ...... ar phospho-STAT5 accumulation.
@en
P2093
M A Weniger
T F E Barth
T Mattfeldt
P2888
P304
P356
10.1038/SJ.ONC.1209151
P407
P577
2006-04-01T00:00:00Z
P5875
P6179
1017563236