Biological assay challenges from compound solubility: strategies for bioassay optimization.
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De novo discovery of serotonin N-acetyltransferase inhibitorsEffect of natural and semisynthetic pseudoguianolides on the stability of NF-κB:DNA complex studied by agarose gel electrophoresisA Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepaciaModeling error in experimental assays using the bootstrap principle: understanding discrepancies between assays using different dispensing technologies.Comparison of compound administration methods in biochemical assays: effects on apparent compound potency using either assay-ready compound plates or pin tool-delivered compounds.In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya strictaAdvances in improving the quality and flexibility of compound management.Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 StudyIdentification of Antifungal H+-ATPase Inhibitors with Effect on Plasma Membrane PotentialExploratory analysis of kinetic solubility measurements of a small molecule libraryCharacterization of short-term temperature, exposure, and solubilization effects on library compound quality.Quantification of the effects of ionic strength, viscosity, and hydrophobicity on protein-ligand binding affinity.Solubility at the molecular level: development of a critical aggregation concentration (CAC) assay for estimating compound monomer solubility.Assessing toxicological data quality: basic principles, existing schemes and current limitations.Fragment-based approaches to enzyme inhibitionChemiluminescent nitrogen detection (CLND) to measure kinetic aqueous solubility.Identifying apicoplast-targeting antimalarials using high-throughput compatible approachesSelecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.In vitro models for processes involved in intestinal absorption.Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety.Matching the power of high throughput screening to the chemical diversity of natural productsDynamic residual complexity of natural products by qHNMR: solution stability of desmethylxanthohumol.Compound management beyond efficiency.Probing the links between in vitro potency, ADMET and physicochemical parameters.Novel platinum(II) compounds with O,S bidentate ligands: synthesis, characterization, antiproliferative properties and biomolecular interactions.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.Corticosteroid production in H295R cells during exposure to 3 endocrine disrupters analyzed with LC-MS/MS.An improved non-enzymatic "DNA ladder assay" for more sensitive and early detection of apoptosis.Photo-enhanced Aqueous Solubilization of an Azo-compoundCompound precipitation in high-concentration DMSO solutions.Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds.4,5-Dimethoxy-2-nitrobenzohydrazides and 1-(1-Benzylpiperidin-4-yl)ethan-1-ones as Potential Antioxidant/Cholinergic Endowed Small Molecule Leads.Preliminary Evaluation of Artemisinin-Cholesterol Conjugates as Potential Drugs for the Treatment of Intractable Forms of Malaria and Tuberculosis.Application of drug efficiency index in drug discovery: a strategy towards low therapeutic dose.In Silico ADME/Tox Predictions
P2860
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P2860
Biological assay challenges from compound solubility: strategies for bioassay optimization.
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Biological assay challenges fr ...... ies for bioassay optimization.
@ast
Biological assay challenges fr ...... ies for bioassay optimization.
@en
type
label
Biological assay challenges fr ...... ies for bioassay optimization.
@ast
Biological assay challenges fr ...... ies for bioassay optimization.
@en
prefLabel
Biological assay challenges fr ...... ies for bioassay optimization.
@ast
Biological assay challenges fr ...... ies for bioassay optimization.
@en
P1433
P1476
Biological assay challenges fr ...... ies for bioassay optimization.
@en
P2093
P304
P356
10.1016/J.DRUDIS.2006.03.004
P577
2006-05-01T00:00:00Z