A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

Item
http://www.wikidata.org/entity/Q33259357
A simplified approach to predict CYP3A-mediated drug-drug interactions at early drug discovery: validation with clinical data.The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo.Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer.In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions.Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities.Biomedical Informatics Approaches to Identifying Drug-Drug Interactions: Application to Insulin Secretagogues.Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection.Aminophylline for treating asthma and chronic obstructive pulmonary disease.Drug-drug interaction and doping, part 2: an in vitro study on the effect of non-prohibited drugs on the phase I metabolic profile of stanozolol.Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research.Translational High-Dimensional Drug Interaction Discovery and Validation Using Health Record Databases and Pharmacokinetics Models.Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors.Quantitative prediction of the extent of drug-drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes.Evaluation of cytochrome P450-mediated drug-drug interactions based on the strategies recommended by regulatory authorities.
P2860

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

Item
http://www.wikidata.org/entity/Q33259357
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A novel model for the predicti ...... tochrome p450 phenotypic data.
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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type
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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prefLabel
A novel model for the predicti ...... tochrome p450 phenotypic data.
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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P1433
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P2093
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A novel model for the predicti ...... tochrome p450 phenotypic data.
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P2093
P304
P31
P356
P433
P478
P577
P698