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The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathwaySos-mediated activation of rac1 by p66shcCDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASPAn effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machineChronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective CellsMolecular basis for the dual function of Eps8 on actin dynamics: bundling and cappingEps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cellsPropagating cell-membrane waves driven by curved activators of actin polymerizationRequirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesisMechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectorsThe SH3 domain of Eps8 exists as a novel intertwined dimerThe Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5EPS8 and E3B1 transduce signals from Ras to RacEps8 in the midst of GTPasesAbi1 is essential for the formation and activation of a WAVE2 signalling complexRegulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complexThe insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticityPalladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cellsIncreased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamicsSra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progressionThe signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migrationEps8 controls actin-based motility by capping the barbed ends of actin filamentsLoss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in miceWAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium.Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing.A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cellsCoordination of membrane and actin cytoskeleton dynamics during filopodia protrusion.Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification.The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formationATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases.Induction of HoxB transcription by retinoic acid requires actin polymerization.Regulation of actin dynamics by WASP and WAVE family proteins.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Giorgio Scita
@ast
Giorgio Scita
@en
Giorgio Scita
@es
Giorgio Scita
@nl
Giorgio Scita
@sl
type
label
Giorgio Scita
@ast
Giorgio Scita
@en
Giorgio Scita
@es
Giorgio Scita
@nl
Giorgio Scita
@sl
prefLabel
Giorgio Scita
@ast
Giorgio Scita
@en
Giorgio Scita
@es
Giorgio Scita
@nl
Giorgio Scita
@sl
P106
P1153
7004138388
P21
P31
P496
0000-0001-7984-1889