The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation. - Wikidata - wikimedia - TriplyDB

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

http://www.wikidata.org/entity/Q33282972

about

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells Receptor tyrosine kinases in the nucleus Regulation of ERBB3/HER3 signaling in cancer Itch is required for lateral line development in zebrafish Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation Cell death or survival promoted by alternative isoforms of ErbB4 Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes.E3 ubiquitin ligases in ErbB receptor quantity control.The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.Endocytosis and intracellular trafficking of ErbBs.Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor.The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition.Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells.Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population.Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo.Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression.Trafficking of receptor tyrosine kinases to the nucleus The role of protease activity in ErbB biology.ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase.Potential of ErbB4 antibodies for cancer therapy.Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase.WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.The E3 ligase Itch in immune regulation and beyond.Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.Signaling by ERBB4 ErbB Receptors and Cancer.ERBB4 binds WWP1/ITCH ubiquitin ligases

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P2860

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

http://www.wikidata.org/entity/Q33282972

description

2007 nî lūn-bûn

@nan

2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

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2007年学术文章

@zh-sg

2007年學術文章

@yue

name

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

@ast

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

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type

label

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

@ast

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

@en

prefLabel

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

@ast

The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

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The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.

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Alberto Gulino

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Claudia Dall'Armi

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Eleonora Maria-Rosaria Puggioni

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Francesca Belleudi

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Gianni Cesareni

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Jasminka Omerovic

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Laura Santangelo

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Lucia Di Marcotullio

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Luigi Frati

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Maria-Rosaria Torrisi

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2849-2862

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scholarly article

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10.1096/FJ.06-7925COM

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11

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21

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Camilla Palumbo

Jordan Marrocco

Maurizio Alimandi

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2007-04-26T00:00:00Z

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6366535

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17463226

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