Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.
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A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet.Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice.Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonistHuman monoclonal antibodies against glucagon receptor improve glucose homeostasis by suppression of hepatic glucose output in diet-induced obese mice.Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathwayMinireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes.Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.An AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon ProductionPancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity.Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides.Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.Upregulated insulin secretion in insulin-resistant mice: evidence of increased islet GLP1 receptor levels and GPR119-activated GLP1 secretion.Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus.A survey of small molecule glucagon receptor antagonists from recent patents (2006 - 2010).The future of incretin-based therapy: novel avenues--novel targets.α-cell role in β-cell generation and regeneration.Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes.Islet α cells and glucagon--critical regulators of energy homeostasis.Glucagon actions on the kidney revisited: possible role in potassium homeostasis.The New Biology and Pharmacology of Glucagon.Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in miceDual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice.Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice.Investigational glucagon receptor antagonists in Phase I and II clinical trials for diabetes.Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism.
P2860
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P2860
Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
@ast
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
@en
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
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type
label
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
@ast
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
@en
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
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prefLabel
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
@ast
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
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Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
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P2093
P1433
P1476
Glucagon receptor antagonism i ...... ce induced by a high-fat diet.
@en
P2093
E Nishimura
M Sörhede Winzell
U G Sidelmann
P2860
P2888
P304
P356
10.1007/S00125-007-0675-3
P50
P577
2007-05-04T00:00:00Z
P5875
P6179
1010783421