Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration
about
Primary cilia utilize glycoprotein-dependent adhesion mechanisms to stabilize long-lasting cilia-cilia contacts.Mitochondrial quality control: decommissioning power plants in neurodegenerative diseasesInitiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome UbiquitinationSignal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to DegenerationMetabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion proteinMahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R proteinFunctional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.Review: contribution of transgenic models to understanding human prion disease.Nonspecific binding limits the number of proteins in a cell and shapes their interaction networks.Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion diseaseCytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteinsInherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.Protein targeting and degradation are coupled for elimination of mislocalized proteins.Prion protein at the crossroads of physiology and disease.Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.RML prions act through Mahogunin and Attractin-independent pathways.Shades of meaning: the pigment-type switching system as a tool for discovery.Prion propagation, toxicity and degradation.Proteomic analysis of prion diseases: creating clarity or causing confusion?Protein quality control system in neurodegeneration: a healing company hard to beat but failure is fatal.Prion disease: a tale of folds and strains.Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity.Prion degradation pathways: Potential for therapeutic intervention.Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease.Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms.Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101.Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.Prions disturb post-Golgi trafficking of membrane proteins.Lysosomal Quality Control in Prion Diseases.Selective endosomal microautophagy is starvation-inducible in DrosophilaStructural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria.Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response.Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins.Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane.Msp1: patrolling mitochondria for lost proteins.Mahogunin-mediated α-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
P2860
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P2860
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Functional depletion of mahogu ...... ntributes to neurodegeneration
@ast
Functional depletion of mahogu ...... ntributes to neurodegeneration
@en
type
label
Functional depletion of mahogu ...... ntributes to neurodegeneration
@ast
Functional depletion of mahogu ...... ntributes to neurodegeneration
@en
prefLabel
Functional depletion of mahogu ...... ntributes to neurodegeneration
@ast
Functional depletion of mahogu ...... ntributes to neurodegeneration
@en
P2860
P1433
P1476
Functional depletion of mahogu ...... ntributes to neurodegeneration
@en
P2093
Oishee Chakrabarti
P2860
P304
P356
10.1016/J.CELL.2009.03.042
P407
P577
2009-06-01T00:00:00Z