Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1
about
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypesChallenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV ReservoirsSIV genome-wide pyrosequencing provides a comprehensive and unbiased view of variation within and outside CD8 T lymphocyte epitopesDistinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope SpecificityStructure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infectionSwitching and emergence of CTL epitopes in HIV-1 infectionHuman leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationshipsDeclines in highly active antiretroviral therapy initiation at CD4 cell counts ≤ 200 cells/μL and the contribution of diagnosis of HIV at CD4 cell counts ≤ 200 cells/μL in British Columbia, CanadaAdaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.Human immunodeficiency virus vaccine trialsT-cell epitope prediction: rescaling can mask biological variation between MHC molecules.Integrating gene and protein expression data with genome-scale metabolic networks to infer functional pathwaysStatistical resolution of ambiguous HLA typing dataThe evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLA-associated risk of AIDS progression.The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAP.Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.Frequent toggling between alternative amino acids is driven by selection in HIV-1The distribution of CTL epitopes in HIV-1 appears to be random, and similar to that of other proteomes.HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1.Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.HLA-associated immune pressure on Gag protein in CRF01_AE-infected individuals and its association with plasma viral load.Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.CodonTest: modeling amino acid substitution preferences in coding sequences.Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.Quantifying the impact of human immunodeficiency virus-1 escape from cytotoxic T-lymphocytes.Maintenance or emergence of chronic phase secondary cytotoxic T lymphocyte responses after loss of acute phase immunodominant responses does not protect SIV-infected rhesus macaques from disease progression.Impaired replication capacity of acute/early viruses in persons who become HIV controllers.Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma are associated with nonprogressive HIV-1 infection.Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressureRecurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infectionsImproved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection.Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responsesViral diversity and diversification of major non-structural genes vif, vpr, vpu, tat exon 1 and rev exon 1 during primary HIV-1 subtype C infection.Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infectionFluidity of HIV-1-specific T-cell responses during acute and early subtype C HIV-1 infection and associations with early disease progression.Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada.Early immune adaptation in HIV-1 revealed by population-level approaches.
P2860
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P2860
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Evidence of differential HLA c ...... sory/regulatory genes of HIV-1
@ast
Evidence of differential HLA c ...... sory/regulatory genes of HIV-1
@en
Evidence of differential HLA c ...... ory/regulatory genes of HIV-1.
@nl
type
label
Evidence of differential HLA c ...... sory/regulatory genes of HIV-1
@ast
Evidence of differential HLA c ...... sory/regulatory genes of HIV-1
@en
Evidence of differential HLA c ...... ory/regulatory genes of HIV-1.
@nl
prefLabel
Evidence of differential HLA c ...... sory/regulatory genes of HIV-1
@ast
Evidence of differential HLA c ...... sory/regulatory genes of HIV-1
@en
Evidence of differential HLA c ...... ory/regulatory genes of HIV-1.
@nl
P2093
P2860
P50
P1433
P1476
Evidence of differential HLA c ...... sory/regulatory genes of HIV-1
@en
P2093
Carl Kadie
Celia Chui
James Szinger
Jonathan Carlson
Marcus Daniels
Nicole Frahm
P Richard Harrigan
Theresa Mo
P2860
P356
10.1371/JOURNAL.PPAT.0030094
P50
P577
2007-07-01T00:00:00Z