Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin
about
Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in miceCalcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraineTreatment of migraine attacks based on the interaction with the trigemino-cerebrovascular systemCalcitonin gene-related peptide: physiology and pathophysiologyProinflammatory mediators and migraine pathogenesis: moving towards CGRP as a target for a novel therapeutic classEndosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteriesCalcitonin gene-related peptide receptor antagonists for the treatment of migraine: a patent review.Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of MigraineAnalysis of the proteolysis of bioactive peptides using a peptidomics approach.The Dose Proportionality of Telcagepant after Administration of Single Oral and Intravenous Doses in Healthy Adult SubjectsCGRP receptor antagonists: an expanding drug class for acute migraine?ACS chemical neuroscience molecule spotlight on Telcagepant (MK-0974).Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraineQuinoline derivatives: candidate drugs for a class B G-protein coupled receptor, the calcitonin gene-related peptide receptor, a cause of migraines.Calcitonin gene-related peptide receptor antagonists for migraine.Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine.CGRP receptor antagonists: design and screening.Asymmetric organocatalysis at the service of medicinal chemistryCGRP antagonists and antibodies for the treatment of migraine.Novel strategies for the treatment of migraine attacks via the CGRP, serotonin, dopamine, PAC1, and NMDA receptors.Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor AntagonistInhibition of nitric oxide synthesis in mouse macrophage cells by feverfew supercritical extract.[(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide ReceptorControl of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries.Single- and multiple-dose pharmacokinetics and tolerability of telcagepant, an oral calcitonin gene-related peptide receptor antagonist, in adults.Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats.Telcagepant is a new oral treatment for migraine.Lack of hemodynamic interaction between CGRP-receptor antagonist telcagepant (MK-0974) and sumatriptan: results from a randomized study in patients with migraine.Calcitonin gene-related peptide and migraine with aura: A systematic review.A randomized, placebo-controlled study of the effects of telcagepant on exercise time in patients with stable angina.
P2860
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P2860
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@ast
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@en
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@nl
type
label
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@ast
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@en
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@nl
prefLabel
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@ast
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@en
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@nl
P2093
P356
P1476
Potent, orally bioavailable ca ...... hydro-1H-imidazo[4,5-b]pyridin
@en
P2093
Anthony W Shaw
Bradley K Wong
Christopher A Salvatore
Christopher S Burgey
Cynthia M Miller-Stein
Daniel V Paone
Diem N Nguyen
James C Hershey
James Z Deng
Joseph P Vacca
P304
P356
10.1021/JM070668P
P407
P577
2007-10-11T00:00:00Z