A small molecule microarray platform to select RNA internal loop-ligand interactions.
about
Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNAIdentification of potential conserved RNA secondary structure throughout influenza A coding regionsDesign of a small molecule against an oncogenic noncoding RNAApproaches to Validate and Manipulate RNA Targets with Small Molecules in CellsTherapeutics development in myotonic dystrophy type 1.Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.Selection of bead-displayed, PNA-encoded chemicals.A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections.Small-molecule microarrays as tools in ligand discovery.Small molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intronRational and modular design of potent ligands targeting the RNA that causes myotonic dystrophy 2.Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.Discovering ligands for a microRNA precursor with peptoid microarrays.Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactionsTwo-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides.Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophyMethods to enable the design of bioactive small molecules targeting RNA.Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitorA microarray-based method to perform nucleic acid selections.The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophiesDefining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysisNew trends in aminoglycosides use.Secondary structure of a conserved domain in an intron of influenza A M1 mRNAChemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcriptsRationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.Folding and finding RNA secondary structure.A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome.Probing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening.Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations.A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase activity.Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays.Structure-activity relationships through sequencing (StARTS) defines optimal and suboptimal RNA motif targets for small moleculesStructural characterization of naturally occurring RNA single mismatches.Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing.Features of modularly assembled compounds that impart bioactivity against an RNA target.Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches.A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions.Sequence-based design of bioactive small molecules that target precursor microRNAs.Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA
P2860
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P2860
A small molecule microarray platform to select RNA internal loop-ligand interactions.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@ast
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@en
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@nl
type
label
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@ast
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@en
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@nl
prefLabel
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@ast
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@en
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@nl
P2093
P356
P1433
P1476
A small molecule microarray platform to select RNA internal loop-ligand interactions.
@en
P2093
Alexei Pushechnikov
Jessica L Childs-Disney
Matthew D Disney
Olga Aminova
P304
P356
10.1021/CB700174R
P577
2007-11-02T00:00:00Z