Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. - Wikidata - wikimedia - TriplyDB

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

http://www.wikidata.org/entity/Q33311290

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The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering Virological and cellular roles of the transcriptional coactivator LEDGF/p75 Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity Structural basis for functional tetramerization of lentiviral integrase DNA minicircles clarify the specific role of DNA structure on retroviral integration p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes Allosteric Inhibition of Human Immunodeficiency Virus Integrase Functional and structural characterization of the integrase from the prototype foamy virus A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain Retroviral DNA Integration LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase.Mass spectrometry-based footprinting of protein-protein interactions Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.The SET complex acts as a barrier to autointegration of HIV-1 Host cell factors in HIV replication: meta-analysis of genome-wide studies.Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.Novel approaches to inhibiting HIV-1 replication.The foamy virus genome remains unintegrated in the nuclei of G1/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus.LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.Deciphering the code for retroviral integration target site selection HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 Methods for integration site distribution analyses in animal cell genomes Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in Brazilian HIV-1+ individuals Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs Expression analysis of LEDGF/p75, APOBEC3G, TRIM5alpha, and tetherin in a Senegalese cohort of HIV-1-exposed seronegative individuals.Molecular mechanisms of retroviral integration site selection.Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.

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Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

http://www.wikidata.org/entity/Q33311290

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@ast

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@en

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@nl

type

label

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@ast

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@en

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@nl

prefLabel

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@ast

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@en

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@nl

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JOURNAL.PONE.0001340

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Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

@en

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Charles Berry

http://www.w3.org/2001/XMLSchema#string

Dyana Saenz

http://www.w3.org/2001/XMLSchema#string

Eric Poeschla

http://www.w3.org/2001/XMLSchema#string

Heather M Marshall

http://www.w3.org/2001/XMLSchema#string

Keshet Ronen

http://www.w3.org/2001/XMLSchema#string

Manuel Llano

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P2860

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

Genome sequencing in microfabricated high-density picolitre reactors

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

Gene transfer in humans using a conditionally replicating lentiviral vector

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

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e1340

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scholarly article

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10.1371/JOURNAL.PONE.0001340

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P433

12

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2

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Frederic D. Bushman

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2007-12-19T00:00:00Z

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5757035

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18092005

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2129110

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