AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.
about
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory elementThe contribution of mouse models to the understanding of constitutional thrombocytopeniaCDK6 as a key regulator of hematopoietic and leukemic stem cell activationThe orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cellsQuiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1.Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cellsDevelopment of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutationHmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice.The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.RUNX genes find a niche in stem cell biology.Runx1 loss minimally impacts long-term hematopoietic stem cellsRUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingRunx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.RUNX1 induces DNA replication independent of active DNA demethylation at SPI1 regulatory regions.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndromeCell cycle and developmental control of hematopoiesis by Runx1.Human adipose tissue contains erythroid progenitors expressing fetal hemoglobin.Role of the RUNX1-EVI1 fusion gene in leukemogenesis.Genetic control of quiescence in hematopoietic stem cells.Identification of Hematopoietic Stem Cell Engraftment Genes in Gene Therapy Studies.A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiationCore binding factor at the crossroads: determining the fate of the HSC.RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling.RUNX1: A microRNA hub in normal and malignant hematopoiesis.A role for RUNX1 in hematopoiesis and myeloid leukemia.The RUNX1-PU.1 axis in the control of hematopoiesis.Novel function of the unique N-terminal region of RUNX1c in B cell growth regulation.C/EBPα deregulation as a paradigm for leukemogenesis.Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.5'RUNX1-3'USP42 chimeric gene in acute myeloid leukemia can occur through an insertion mechanism rather than translocation and may be mediated by genomic segmental duplications.ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation.MEIS1 regulates early erythroid and megakaryocytic cell fate.Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation.Evaluation of CCAAT/Enhancer Binding Protein (C/EBP) Alpha (CEBPA) and Runt-Related Transcription Factor 1 (RUNX1) Expression in Patients with De Novo Acute Myeloid Leukemia.Precocious Phenotypic Transcription-Factor Expression During Early Development.Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development.
P2860
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P2860
AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@ast
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@en
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@nl
type
label
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@ast
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@en
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@nl
prefLabel
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@ast
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@en
AML1/Runx1 negatively regulate ...... cells in adult hematopoiesis.
@nl
P2093
P1476
AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis
@en
P2093
Masahito Kawazu
Masataka Takeshita
Mineo Kurokawa
Seishi Ogawa
Shigeru Chiba
Susumu Goyama
Takashi Asai
P304
P356
10.4049/JIMMUNOL.180.7.4402
P407
P577
2008-04-01T00:00:00Z