High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
about
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrateGelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain.Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screeningDiscovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.Using fluorogenic peptide substrates to assay matrix metalloproteinases.New strategies for targeting matrix metalloproteinasesThe history of matrix metalloproteinases: milestones, myths, and misperceptions.Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.Synthesis and biological applications of collagen-model triple-helical peptides.Selective MMP13 inhibitors.Clinical implications of compounds designed to inhibit ECM-modifying metalloproteinases.Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).Recent Research Advances in Selective Matrix Metalloproteinase-13 Inhibitors as Anti-Osteoarthritis Agents.A competitive co-cultivation assay for cancer drug specificity evaluation.The synthesis and application of Fmoc-Lys(5-Fam) building blocks.SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes.
P2860
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P2860
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
High throughput screening of p ...... triple-helical FRET substrate.
@ast
High throughput screening of p ...... triple-helical FRET substrate.
@en
High throughput screening of p ...... triple-helical FRET substrate.
@nl
type
label
High throughput screening of p ...... triple-helical FRET substrate.
@ast
High throughput screening of p ...... triple-helical FRET substrate.
@en
High throughput screening of p ...... triple-helical FRET substrate.
@nl
prefLabel
High throughput screening of p ...... triple-helical FRET substrate.
@ast
High throughput screening of p ...... triple-helical FRET substrate.
@en
High throughput screening of p ...... triple-helical FRET substrate.
@nl
P2093
P2860
P1476
High throughput screening of p ...... triple-helical FRET substrate.
@en
P2093
Gregg B Fields
Janelle L Lauer-Fields
Peter Hodder
Peter S Chase
Roma Stawikowska
S Adrian Saldanha
P2860
P304
P356
10.1016/J.BMC.2008.03.004
P407
P577
2008-03-06T00:00:00Z