An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
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Overlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functionsDistinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cellsSafety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors.Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15.Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.Memories that last forever: strategies for optimizing vaccine T-cell memory.Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein.Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation.IL-18 is required for self-reactive T cell expansion in NOD mice.Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expressionPathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.Development of Membrane-Bound GM-CSF and IL-18 as an Effective Tumor Vaccine.IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells.Inflammatory monocytes activate memory CD8(+) T and innate NK lymphocytes independent of cognate antigen during microbial pathogen invasionCombination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice.Anti-viral CD8 T cells and the cytokines that they loveTargeted antigen delivery to DEC-205⁺ dendritic cells for tolerogenic vaccinationThe presence of T cell epitopes is important for induction of antibody responses against antigens directed to DEC205+ dendritic cells.Inflammation enhances the vaccination potential of CD40-activated B cells in mice.Role of interleukin-18 in the pathophysiology of allergic diseases.PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model.
P2860
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P2860
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
@ast
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
@en
type
label
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
@ast
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
@en
prefLabel
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
@ast
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
@en
P2093
P2860
P1433
P1476
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
@en
P2093
Hiroaki Hemmi
Olga Mizenina
Ralph M Steinman
Shoko Kuroda
Yoshiko Iwai
P2860
P356
10.1371/JOURNAL.PONE.0002404
P407
P577
2008-06-11T00:00:00Z