Type I interferon: potential therapeutic target for psoriasis? - Wikidata - wikimedia - TriplyDB

Type I interferon: potential therapeutic target for psoriasis?

Type I interferon: potential therapeutic target for psoriasis?

http://www.wikidata.org/entity/Q33354097

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Integrated network analysis of transcriptomic and proteomic data in psoriasis The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings Putting together the psoriasis puzzle: an update on developing targeted therapies EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells Effect of IL-17 receptor A blockade with brodalumab in inflammatory diseases IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis Random generalized linear model: a highly accurate and interpretable ensemble predictor Novel factors in the pathogenesis of psoriasis and potential drug candidates are found with systems biology approach A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment.Integrative RNA-seq and microarray data analysis reveals GC content and gene length biases in the psoriasis transcriptome Identifying disease-specific genes based on their topological significance in protein networks.Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA).Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity.Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis.Tristetraprolin expression by keratinocytes controls local and systemic inflammation.Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era Hypomorphic A20 expression confers susceptibility to psoriasis.Cytokine-producing dendritic cells in the pathogenesis of inflammatory skin diseases.Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin.Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis.Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease Transcriptome classification reveals molecular subtypes in psoriasis Genomic signatures characterize leukocyte infiltration in myositis muscles.Cross-study homogeneity of psoriasis gene expression in skin across a large expression range.Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases.Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology Pathway activity inference for multiclass disease classification through a mathematical programming optimisation framework.Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans.Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients Microbiomic signatures of psoriasis: feasibility and methodology comparison.Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin.Multi-TGDR: a regularization method for multi-class classification in microarray experiments.Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation.Computational approach to identify enzymes that are potential therapeutic candidates for psoriasis.Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation.Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models.

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P2860

Type I interferon: potential therapeutic target for psoriasis?

http://www.wikidata.org/entity/Q33354097

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Type I interferon: potential therapeutic target for psoriasis?

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Type I interferon: potential therapeutic target for psoriasis?

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Type I interferon: potential therapeutic target for psoriasis?

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Type I interferon: potential therapeutic target for psoriasis?

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Type I interferon: potential therapeutic target for psoriasis?

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Anthony Coyle

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Bahija Jallal

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P2860

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Interferon-alpha/beta-mediated innate immune mechanisms in dermatomyositis

IRF-7 is the master regulator of type-I interferon-dependent immune responses

IRF family of transcription factors as regulators of host defense

Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

The nature of the principal type 1 interferon-producing cells in human blood

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

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