A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators
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RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice siteThe Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate RetinaIdentification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screeningDigoxin suppresses HIV-1 replication by altering viral RNA processingIdentification of a novel function of CX-4945 as a splicing regulatorA broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicingRNA and diseaseA high-throughput screening assay for determining cellular levels of total tau protein.Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.Pharmacologic correction of dominant-negative GH1 deficiency causing mutations.An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretionSignaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins.An alternative splicing network links cell-cycle control to apoptosisPsoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing.Networking in a global world: establishing functional connections between neural splicing regulators and their target transcriptsStalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation.The genomic architecture of sporadic heart failureBottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNARectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomiaIdentification of small molecule inhibitors of pre-mRNA splicing.Alternative Splicing Shapes the Phenotype of a Mutation in BBS8 To Cause Nonsyndromic Retinitis PigmentosaA quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2BmRNA transcript diversity creates new opportunities for pharmacological intervention.SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNASplicing inhibition of U2AF65 leads to alternative exon skipping.Small Molecule Modulators of Pre-mRNA Splicing in Cancer TherapyTargeting RNA splicing for disease therapy.In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide MetforminCD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradationGlobal analysis of allele-specific expression in Arabidopsis thaliana.Tau alternative splicing in familial and sporadic tauopathies.Alternative splicing variability: exactly how similar are two identical cells?Abnormalities in Alternative Splicing of Apoptotic Genes and Cardiovascular Diseases.Suppression of Adenovirus Replication by Cardiotonic Steroids.Cardiac glycosides correct aberrant splicing of IKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3.Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.
P2860
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P2860
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
A high-throughput screening st ...... lternative splicing modulators
@ast
A high-throughput screening st ...... lternative splicing modulators
@en
type
label
A high-throughput screening st ...... lternative splicing modulators
@ast
A high-throughput screening st ...... lternative splicing modulators
@en
prefLabel
A high-throughput screening st ...... lternative splicing modulators
@ast
A high-throughput screening st ...... lternative splicing modulators
@en
P2093
P2860
P356
P1476
A high-throughput screening st ...... lternative splicing modulators
@en
P2093
Chia-Ho Lin
Douglas L Black
Julia Nikolic
Peter Stoilov
Robert Damoiseaux
P2860
P304
11218-11223
P356
10.1073/PNAS.0801661105
P407
P577
2008-08-04T00:00:00Z