A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators - Wikidata - wikimedia - TriplyDB

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

http://www.wikidata.org/entity/Q33357493

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RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site The Musashi 1 Controls the Splicing of Photoreceptor-Specific Exons in the Vertebrate Retina Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening Digoxin suppresses HIV-1 replication by altering viral RNA processing Identification of a novel function of CX-4945 as a splicing regulator A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing RNA and disease A high-throughput screening assay for determining cellular levels of total tau protein.Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.Pharmacologic correction of dominant-negative GH1 deficiency causing mutations.An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion Signaling mechanisms that link salt retention to hypertension: endogenous ouabain, the Na(+) pump, the Na(+)/Ca(2+) exchanger and TRPC proteins.An alternative splicing network links cell-cycle control to apoptosis Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing.Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation.The genomic architecture of sporadic heart failure Bottom-up design of small molecules that stimulate exon 10 skipping in mutant MAPT pre-mRNA Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia Identification of small molecule inhibitors of pre-mRNA splicing.Alternative Splicing Shapes the Phenotype of a Mutation in BBS8 To Cause Nonsyndromic Retinitis Pigmentosa A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B mRNA transcript diversity creates new opportunities for pharmacological intervention.SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA Splicing inhibition of U2AF65 leads to alternative exon skipping.Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy Targeting RNA splicing for disease therapy.In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation Global analysis of allele-specific expression in Arabidopsis thaliana.Tau alternative splicing in familial and sporadic tauopathies.Alternative splicing variability: exactly how similar are two identical cells?Abnormalities in Alternative Splicing of Apoptotic Genes and Cardiovascular Diseases.Suppression of Adenovirus Replication by Cardiotonic Steroids.Cardiac glycosides correct aberrant splicing of IKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3.Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.

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A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

http://www.wikidata.org/entity/Q33357493

description

2008 nî lūn-bûn

@nan

2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年学术文章

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2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

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name

A high-throughput screening st ...... lternative splicing modulators

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A high-throughput screening st ...... lternative splicing modulators

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type

label

A high-throughput screening st ...... lternative splicing modulators

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prefLabel

A high-throughput screening st ...... lternative splicing modulators

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Proceedings of the National Academy of Sciences of the United States of America

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A high-throughput screening st ...... lternative splicing modulators

@en

P2093

Chia-Ho Lin

http://www.w3.org/2001/XMLSchema#string

Douglas L Black

http://www.w3.org/2001/XMLSchema#string

Julia Nikolic

http://www.w3.org/2001/XMLSchema#string

Peter Stoilov

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Robert Damoiseaux

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P2860

Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4

SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

An in vivo reporter system for measuring increased inclusion of exon 7 in SMN2 mRNA: potential therapy of SMA

Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients

Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1

Arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer: altered interactions and mechanisms for functionally antagonistic FTDP-17 mutations Delta280K AND N279K

Pre-mRNA splicing and human disease

Use of transcriptional synergy to augment sensitivity of a splicing reporter assay

Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors.

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18678901

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