Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
about
C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cellsMembrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities.Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.Charge density influences C1 domain ligand affinity and membrane interactionsMolecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligandsThe synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell lineDiacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cellsMolecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester.Wealth of opportunity - the C1 domain as a target for drug development.PKC in Regenerative Therapy: New Insights for Old Targets.N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activityConformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteinsPolar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agentsConformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengthPhosphorylation of alpha6-tubulin by protein kinase Calpha activates motility of human breast cells.Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?Development of diacyltetrol lipids as activators for the C1 domain of protein kinase C.Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.The C1 domain of Vav3, a novel potential therapeutic target.Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.Characterization of AJH-836, a DAG-lactone with selectivity for novel PKC isozymes.Elucidating the interaction of γ-hydroxymethyl-γ-butyrolactone substituents with model membranes and protein kinase C-C1 domains.
P2860
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P2860
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Conformationally constrained a ...... elective biological activities
@ast
Conformationally constrained a ...... elective biological activities
@en
type
label
Conformationally constrained a ...... elective biological activities
@ast
Conformationally constrained a ...... elective biological activities
@en
prefLabel
Conformationally constrained a ...... elective biological activities
@ast
Conformationally constrained a ...... elective biological activities
@en
P2093
P2860
P356
P1476
Conformationally constrained a ...... elective biological activities
@en
P2093
Alyson Baker
Christopher C Lai
Damon A Parrish
Dehui Duan
Dina M Sigano
Howard A Young
Jae-Uk Chung
James A Kelley
Jean-Philip Truman
P2860
P304
P356
10.1021/JM8001907
P407
P577
2008-08-13T00:00:00Z