HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.
about
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypesHIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elementsExtracellular vesicles during Herpes Simplex Virus type 1 infection: an inquireRemodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceThe evolution of natural killer cell receptorsExosomes: Implications in HIV-1 PathogenesisConformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assemblyStructural basis of evasion of cellular adaptive immunity by HIV-1 NefOne protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.Proteomic-based identification of CD4-interacting proteins in human primary macrophagesThe identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancementModeling of HIV-1 infection: insights to the role of monocytes/macrophages, latently infected T4 cells, and HAART regimesKnow Thyself: NK-Cell Inhibitory Receptors Prompt Self-Tolerance, Education, and Viral Control.Role of Coatomer Protein I in Virus Replication.A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection.Can Selective MHC Downregulation Explain the Specificity and Genetic Diversity of NK Cell Receptors?An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex.Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef actionSequence- and interactome-based prediction of viral protein hotspots targeting host proteins: a case study for HIV Nef.HIV protein sequence hotspots for crosstalk with host hub proteins.HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.Differential microRNA expression profile between stimulated PBMCs from HIV-1 infected elite controllers and viremic progressors.Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.Mathematical model of the Tat-Rev regulation of HIV-1 replication in an activated cell predicts the existence of oscillatory dynamics in the synthesis of viral componentsMisdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells.Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways.An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.HLA-C and HIV-1: friends or foes?Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function.Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo.Identification of Binding Mode and Prospective Structural Features of Novel Nef Protein Inhibitors as Potential Anti-HIV Drugs.Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells.The frantic play of the concealed HIV envelope cytoplasmic tail.Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.Mechanisms of HIV-1 Nef function and intracellular signaling.
P2860
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P2860
HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
HIV-1 Nef targets MHC-I and CD ...... -dependent pathway in T cells.
@ast
HIV-1 Nef targets MHC-I and CD ...... -dependent pathway in T cells.
@en
type
label
HIV-1 Nef targets MHC-I and CD ...... -dependent pathway in T cells.
@ast
HIV-1 Nef targets MHC-I and CD ...... -dependent pathway in T cells.
@en
prefLabel
HIV-1 Nef targets MHC-I and CD ...... -dependent pathway in T cells.
@ast
HIV-1 Nef targets MHC-I and CD ...... -dependent pathway in T cells.
@en
P2093
P2860
P1433
P1476
HIV-1 Nef targets MHC-I and CD ...... -dependent pathway in T cells.
@en
P2093
Jeremiah F Roeth
Jolie A Leonard
Kathleen L Collins
Malinda R Schaefer
P2860
P304
P356
10.1371/JOURNAL.PPAT.1000131
P577
2008-08-22T00:00:00Z