Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.
about
Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidasePediatric phase I trial design using maximum target inhibition as the primary endpointA high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiationSynthesis of 1,2,3-triazol-1-yl-methaneboronic acids via click chemistry: an easy access to a new potential scaffold for protease inhibitors.A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapyTherapeutic potential of boron-containing compounds.Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.Recent patents of dipeptidyl peptidase IV inhibitors.Molecular recognition with boronic acids-applications in chemical biology.From the Test Tube to the Treatment Room: Fundamentals of Boron-containing Compounds and their Relevance to Dermatology.Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase.Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents.Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors.Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides.DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imagingA novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.Dipeptidyl peptidases and related proteins: multifaceted markers and therapeutic targets.
P2860
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P2860
Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Dipeptide boronic acid inhibit ...... d in vivo efficacy and safety.
@ast
Dipeptide boronic acid inhibit ...... d in vivo efficacy and safety.
@en
type
label
Dipeptide boronic acid inhibit ...... d in vivo efficacy and safety.
@ast
Dipeptide boronic acid inhibit ...... d in vivo efficacy and safety.
@en
prefLabel
Dipeptide boronic acid inhibit ...... d in vivo efficacy and safety.
@ast
Dipeptide boronic acid inhibit ...... d in vivo efficacy and safety.
@en
P2093
P356
P1476
Dipeptide boronic acid inhibit ...... d in vivo efficacy and safety.
@en
P2093
Amrita K Chiluwal
Beth A Connolly
David G Sanford
Diane E Peters
Hlaing Maw
Jack H Lai
James L Sudmeier
Matthew T Dimare
Sarah E Healey
P304
P356
10.1021/JM800390N
P407
P577
2008-09-11T00:00:00Z