Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency.
about
Activated protein C: A regulator of human skin epidermal keratinocyte functionPneumonia, thrombosis and vascular diseaseActivated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.Extracellular histones are major mediators of death in sepsis.The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implicationsAn accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia.A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia.Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation.Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge.Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury.Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.Recombinant human activated protein C: current insights into its mechanism of actionActivation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic miceProtective mechanisms of activated protein C in severe inflammatory disorders.The protein C pathway and pathologic processesSystemic versus localized coagulation activation contributing to organ failure in critically ill patients.The protein C pathway in intestinal barrier function: challenging the hemostasis paradigm.Targeting activated protein C to treat hemophilia.Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland.A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice.Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring.Activated protein C binds directly to Tie2: possible beneficial effects on endothelial barrier function.Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor.Endogenous protein C inhibits activation of coagulation and transiently lowers bacterial outgrowth in murine Escherichia coli peritonitis.
P2860
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P2860
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Acute inflammation is exacerba ...... a severe protein C deficiency.
@ast
Acute inflammation is exacerba ...... a severe protein C deficiency.
@en
type
label
Acute inflammation is exacerba ...... a severe protein C deficiency.
@ast
Acute inflammation is exacerba ...... a severe protein C deficiency.
@en
prefLabel
Acute inflammation is exacerba ...... a severe protein C deficiency.
@ast
Acute inflammation is exacerba ...... a severe protein C deficiency.
@en
P2093
P2860
P1433
P1476
Acute inflammation is exacerba ...... a severe protein C deficiency.
@en
P2093
Angelina J Lay
Deborah Donahue
Francis J Castellino
Meng-Ju Tsai
P2860
P304
P356
10.1182/BLOOD-2006-07-037945
P407
P577
2006-10-17T00:00:00Z