Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.
about
Structural basis for alginate secretion across the bacterial outer membraneProton-dependent gating and proton uptake by Wzx support O-antigen-subunit antiport across the bacterial inner membraneSecond-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-raftsSphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ActivityPotentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel HydroxypyrazolinesCFTR Modulators for the Treatment of Cystic Fibrosis.Cystic fibrosis transmembrane conductance regulator protein repair as a therapeutic strategy in cystic fibrosisCystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.Proteomic identification of calumenin as a G551D-CFTR associated protein.Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanismsRecent advances and new perspectives in targeting CFTR for therapy of cystic fibrosis and enterotoxin-induced secretory diarrheas.Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator.Cystic fibrosis transmembrane regulator correctors and potentiators.Specific stabilization of CFTR by phosphatidylserine.Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.Functional reconstitution and channel activity measurements of purified wildtype and mutant CFTR protein.G551D-CFTR needs more bound actin than wild-type CFTR to maintain its presence in plasma membranes.Prevalence of meconium ileus marks the severity of mutations of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene.Function and regulation of TRPM7, as well as intracellular magnesium content, are altered in cells expressing ΔF508-CFTR and G551D-CFTR.
P2860
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P2860
Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
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2009年学术文章
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2009年學術文章
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name
Direct interaction of a small- ...... ssociated with severe disease.
@ast
Direct interaction of a small- ...... ssociated with severe disease.
@en
type
label
Direct interaction of a small- ...... ssociated with severe disease.
@ast
Direct interaction of a small- ...... ssociated with severe disease.
@en
prefLabel
Direct interaction of a small- ...... ssociated with severe disease.
@ast
Direct interaction of a small- ...... ssociated with severe disease.
@en
P2093
P356
P1433
P1476
Direct interaction of a small- ...... ssociated with severe disease.
@en
P2093
Christine E Bear
Mohabir Ramjeesingh
Stan Pasyk
P304
P356
10.1042/BJ20081424
P407
P577
2009-02-01T00:00:00Z