A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complex
about
Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura.Measuring soluble platelet glycoprotein VI in human plasma by ELISA.Proteolysis of platelet receptors in humans and other species.Properties of soluble glycoprotein VI, a potential platelet activation biomarker.Elevated Soluble Platelet Glycoprotein VI Levels in Patients After Living Donor Liver Transplantation.Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks.Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation.Targeting GPVI as a novel antithrombotic strategy.The ABCC4 membrane transporter modulates platelet aggregation.The future of glycoprotein VI as an antithrombotic target.The control of blood platelets by cAMP signalling.Model systems for platelet receptor shedding.Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool.The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents.Platelet Activation Assessed by Glycoprotein VI/Platelet Ratio Is Associated With Portal Vein Thrombosis After Hepatectomy and Splenectomy in Patients With Liver Cirrhosis.Translational Implications of Platelets as Vascular First Responders.Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding.Elevated soluble platelet glycoprotein VI is a useful marker for DVT in postoperative patients treated with edoxaban.
P2860
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P2860
A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complex
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A novel antiplatelet antibody ...... c receptor gamma-chain complex
@ast
A novel antiplatelet antibody ...... c receptor gamma-chain complex
@en
type
label
A novel antiplatelet antibody ...... c receptor gamma-chain complex
@ast
A novel antiplatelet antibody ...... c receptor gamma-chain complex
@en
prefLabel
A novel antiplatelet antibody ...... c receptor gamma-chain complex
@ast
A novel antiplatelet antibody ...... c receptor gamma-chain complex
@en
P2093
P2860
P356
P1476
A novel antiplatelet antibody ...... c receptor gamma-chain complex
@en
P2093
Hiroshi Takayama
Jiro Hirose
Kamon Shirakawa
Katsuki Naitoh
Kazuyuki Nakayama
Michiru Kurihara
Mikihiko Shinozaki
Motoyasu Honda
Shoji Furusako
Tetsushi Kawahara
P2860
P304
P356
10.1172/JCI32513
P407
P577
2008-05-01T00:00:00Z