Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. - Wikidata - wikimedia - TriplyDB

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

http://www.wikidata.org/entity/Q33399066

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FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies FAM83B mediates EGFR- and RAS-driven oncogenic transformation Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B Evidence that alpha-synuclein does not inhibit phospholipase D Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor Phospholipase D as a therapeutic target in brain disorders A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism Mammalian phospholipase D physiological and pathological roles Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery Functional regulation of phospholipase D expression in cancer and inflammation Drugs for allosteric sites on receptors ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model.Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration How independent pharmacological screenings in plants and humans led to the discovery of a new family of lipid metabolism inhibitors Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket.A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs.Working towards an exegesis for lipids in biology.Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells.Expression proteomics study to determine metallodrug targets and optimal drug combinations.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Molecular Effects of Doxorubicin on Choline Metabolism in Breast Cancer.PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.Quantitative analysis of glycerophospholipids by LC-MS: acquisition, data handling, and interpretation.ADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways.Cellular and physiological roles for phospholipase D1 in cancer.Francisella tularensis LVS induction of prostaglandin biosynthesis by infected macrophages requires specific host phospholipases and lipid phosphatases Phosphatidic acid plays a regulatory role in clathrin-mediated endocytosis.Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition ¹⁹F NMR indicator displacement assay using a synthetic receptor with appended paramagnetic relaxation agent.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer Development of allosteric modulators of GPCRs for treatment of CNS disorders Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates

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Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

http://www.wikidata.org/entity/Q33399066

description

2009 nî lūn-bûn

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2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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Design of isoform-selective ph ...... late cancer cell invasiveness.

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Design of isoform-selective ph ...... late cancer cell invasiveness.

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Design of isoform-selective ph ...... late cancer cell invasiveness.

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Design of isoform-selective ph ...... late cancer cell invasiveness.

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Design of isoform-selective ph ...... late cancer cell invasiveness.

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Design of isoform-selective ph ...... late cancer cell invasiveness.

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Nature Chemical Biology

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Design of isoform-selective ph ...... late cancer cell invasiveness.

@en

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Ashley L Thomas

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Carlos L Arteaga

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H Alex Brown

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Hyekyung P Cho

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Jason R Buck

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Michelle D Armstrong

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Paige E Selvy

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Sarah A Scott

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Tracy L Criswell

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P2860

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family

A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues

Activation of phospholipase D1 by Cdc42 requires the Rho insert region

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

Ca2+-mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

Phosphohydrolase and transphosphatidylation reactions of two Streptomyces phospholipase D enzymes: covalent versus noncovalent catalysis.

Requirement of phospholipase D1 activity in H-RasV12-induced transformation

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

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108-117

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scholarly article

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10.1038/NCHEMBIO.140

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2

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5

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Craig W. Lindsley

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2009-01-11T00:00:00Z

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19136975

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3798018

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