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Dynamic antibody-binding properties in the pathogenesis of HIT.

Dynamic antibody-binding properties in the pathogenesis of HIT.

http://www.wikidata.org/entity/Q33401163

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Atomic description of the immune complex involved in heparin-induced thrombocytopenia Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.Novel diagnostic assays for heparin-induced thrombocytopenia Emphasis on the Role of PF4 in the Incidence, Pathophysiology and Treatment of Heparin Induced Thrombocytopenia.Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4.Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.Correlation of ELISA optical density with clinical diagnosis of heparin-induced thrombocytopenia: a retrospective study of 104 patients with positive anti-PF4/heparin ELISA.Platelet factor 4/heparin-particle gel immunoassay (PaGIA) is a weak method for heparin-induced thrombocytopenia (HIT) evaluation of post cardio-pulmonary bypass surgery patients.Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia.Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia.Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT).Efficacy and Safety of Fondaparinux in Patients With Suspected Heparin-Induced Thrombocytopenia.A high-value cost conscious approach to minimize heparin induced thrombocytopenia antibody (HITAb) testing using the 4T score.Single-molecule force spectroscopy applied to heparin-induced thrombocytopenia.New platelet functional method for identification of pathogenic antibodies in HIT patients.Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity.Effect of pH and ionic strength on the binding strength of anti-PF4/polyanion antibodies.The diversity of the immune response to the A2 domain of human factor VIII Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment Autoimmune heparin-induced thrombocytopenia.Development of a high-yield expression and purification system for platelet factor 4.5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies.The Role of Single-Molecule Force Spectroscopy in Unraveling Typical and Autoimmune Heparin-induced Thrombocytopenia.Neutrophil accumulation and NET release contribute to thrombosis in HIT

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Dynamic antibody-binding properties in the pathogenesis of HIT.

http://www.wikidata.org/entity/Q33401163

description

2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Dynamic antibody-binding properties in the pathogenesis of HIT.

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Dynamic antibody-binding properties in the pathogenesis of HIT.

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Dynamic antibody-binding properties in the pathogenesis of HIT.

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prefLabel

Dynamic antibody-binding properties in the pathogenesis of HIT.

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Dynamic antibody-binding properties in the pathogenesis of HIT.

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P1476

Dynamic antibody-binding properties in the pathogenesis of HIT.

@en

P2093

Adam Cuker

http://www.w3.org/2001/XMLSchema#string

Ann H Rux

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Bruce S Sachais

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Douglas B Cines

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Gowthami M Arepally

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Jillian L Hinds

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John W Weisel

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Lubica Rauova

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Mortimer Poncz

http://www.w3.org/2001/XMLSchema#string

Serge V Yarovoi

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P2860

Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.

Binding strength and activation state of single fibrinogen-integrin pairs on living cells.

Polymerization of fibrin: specificity, strength, and stability of knob-hole interactions studied at the single-molecule level

Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy.

Direct evidence for specific interactions of the fibrinogen alphaC-domains with the central E region and with each other.

Decision analysis for use of platelet aggregation test, carbon 14-serotonin release assay, and heparin-platelet factor 4 enzyme-linked immunosorbent assay for diagnosis of heparin-induced thrombocytopenia.

Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.

Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA.

Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody.

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.

P304

1137-1142

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scholarly article

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10.1182/BLOOD-2012-01-407262

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5

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120

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Rustem I Litvinov

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2012-05-10T00:00:00Z

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224940352

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22577175

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3412334

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