Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.
about
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Computer-aided Molecular Design of Compounds Targeting Histone Modifying EnzymesExploration of Novel Inhibitors for Class I Histone Deacetylase Isoforms by QSAR Modeling and Molecular Dynamics Simulation AssaysSoftware and resources for computational medicinal chemistryVirtual screening and experimental validation of novel histone deacetylase inhibitorsComparative modeling and benchmarking data sets for human histone deacetylases and sirtuin families.Application of epigenome-modifying small molecules in induced pluripotent stem cells.Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs.Investigations on inhibitors of hedgehog signal pathway: a quantitative structure-activity relationship studyDesign and Validation of FRESH, a Drug Discovery Paradigm Resting on Robust Chemical Synthesis.Discovery of Natural Product-Derived 5-HT1A Receptor Binders by Cheminfomatics Modeling of Known Binders, High Throughput Screening and Experimental Validation.Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor.Quantitative structure-activity relationship analysis and virtual screening studies for identifying HDAC2 inhibitors from known HDAC bioactive chemical libraries.Computational systems chemical biology.Insights from comprehensive multiple receptor docking to HDAC8.Cheminfomatic-based Drug Discovery of Human Tyrosine Kinase Inhibitors.Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation.A Thoroughly Validated Virtual Screening Strategy for Discovery of Novel HDAC3 Inhibitors.A lazy learning-based QSAR classification study for screening potential histone deacetylase 8 (HDAC8) inhibitors.Mechanistic Insights into the Binding of Class IIa HDAC Inhibitors toward Spinocerebellar Ataxia Type-2: A 3D-QSAR and Pharmacophore Modeling ApproachIdentification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: a combined approach of structure-based virtual screening, ADMET prediction and molecular dynamics simulation assay.Molecular modelling on small molecular CDK2 inhibitors: an integrated approach using a combination of molecular docking, 3D-QSAR and pharmacophore modelling.Computer aided drug design and its application to the development of potential drugs for neurodegenerative disorders.Modulation of antitumor immunity with histone deacetylase inhibitors.A steered molecular dynamics mediated hit discovery for histone deacetylases.Computer-Aided Drug Design in Epigenetics.Discovery of a novel histone deacetylase 8 inhibitor by virtual screening
P2860
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P2860
Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Novel inhibitors of human hist ...... , and experimental validation.
@ast
Novel inhibitors of human hist ...... , and experimental validation.
@en
type
label
Novel inhibitors of human hist ...... , and experimental validation.
@ast
Novel inhibitors of human hist ...... , and experimental validation.
@en
prefLabel
Novel inhibitors of human hist ...... , and experimental validation.
@ast
Novel inhibitors of human hist ...... , and experimental validation.
@en
P2093
P356
P1476
Novel inhibitors of human hist ...... , and experimental validation.
@en
P2093
Alan P Kozikowski
Bryan L Roth
Kyle V Butler
Xiang S Wang
P304
P356
10.1021/CI800366F
P577
2009-02-01T00:00:00Z