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Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein

Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein

http://www.wikidata.org/entity/Q33413066

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Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer's disease Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2 Development of a novel DNA aptamer ligand targeting to primary cultured tumor endothelial cells by a cell-based SELEX method Coenzyme Q10 protects human endothelial cells from β-amyloid uptake and oxidative stress-induced injury Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42 Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease.MEGF10 functions as a receptor for the uptake of amyloid-β.Novel mechanism regulating endothelial permeability via T-cadherin-dependent VE-cadherin phosphorylation and clathrin-mediated endocytosis.Sequence-dependent internalization of aggregating peptides Distinct internalization pathways of human amylin monomers and its cytotoxic oligomers in pancreatic cells ApoHRP-based assay to measure intracellular regulatory heme.Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.Role of membrane biophysics in Alzheimer's-related cell pathways.Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-β proteins in the cerebral vasculature Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery.LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's Disease in humans in-vivo.Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling.Imaging the dynamics of endocytosis in live mammalian tissues.Delivery of drugs to the brain via the blood brain barrier using colloidal carriers.Biochemically-defined pools of amyloid-β in sporadic Alzheimer's disease: correlation with amyloid PET.Infection of primary neurons mediated by nipah virus envelope proteins: role of host target cells in antiviral action.Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins.Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1-42) compared to Aβ(1-40).A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity.Extracellular amyloid beta 42 causes necrosis, inhibition of nuclear division, and mitotic disruption under both folate deficient and folate replete conditions as measured by the cytokinesis-block micronucleus cytome assay.The Molecular Physiopathogenesis of Islet Amyloidosis.Lutein protects against β-amyloid peptide-induced oxidative stress in cerebrovascular endothelial cells through modulation of Nrf-2 and NF-κb.Hunting cellular mechanisms underlying the spreading of misfolded protein pathology in the brain.Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane.Direct observation of internalization and ROS generation of amyloid β-peptide in neuronal cells at subcellular resolution.Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism p75NTR is mainly responsible for Aβ toxicity but not for its internalization: a primary study

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Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein

http://www.wikidata.org/entity/Q33413066

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2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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Mechanism of neuronal versus e ...... s disease amyloid beta protein

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Mechanism of neuronal versus e ...... s disease amyloid beta protein

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Joseph F Poduslo

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Karunya K Kandimalla

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Michael W Davidson

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Olenych G Scott

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Smita Fulzele

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P2860

What is the dominant Abeta species in human brain tissue? A review

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

In vivo protein transduction: delivery of a biologically active protein into the mouse

Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane.

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease.

Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding.

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts.

Membrane-disordering effects of beta-amyloid peptides.

Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

Alzheimer disease and cerebrovascular pathology: an update.

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