Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation - Wikidata - wikimedia - TriplyDB

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

http://www.wikidata.org/entity/Q33420391

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Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease Physiopathological function of hematoside (GM3 ganglioside).Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility.Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.Ceramides and glucosylceramides are independent antagonists of insulin signaling Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars.Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue.Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients Gangliosides in cell recognition and membrane protein regulation Membrane microdomains and insulin resistance.Glycosphingolipids--nature, function, and pharmacological modulation.Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis.The twists and turns of sphingolipid pathway in glucose regulation Sphingolipids: the nexus between Gaucher disease and insulin resistance.Glycosphingolipid functions Reduced histone H3K9 acetylation of clock genes and abnormal glucose metabolism in ob/ob mice.Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice.Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms.Systems-level organization of non-alcoholic fatty liver disease progression network.Compounds of the sphingomyelin-ceramide-glycosphingolipid pathways as secondary messenger molecules: new targets for novel therapies for fatty liver disease and insulin resistance.Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors.Endogenous lipid antigens for invariant Natural Killer T cells hold the reins in adipose tissue homeostasis.Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila.Aspartame downregulates 3T3-L1 differentiation.Alpha versus beta: are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3.Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome.

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Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

http://www.wikidata.org/entity/Q33420391

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2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Reducing glycosphingolipid con ...... nesis and reduces inflammation

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Albert K Groen

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Cindy P A A van Roomen

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Cynthia Arbeeny

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Hermen S Overkleeft

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Ingar Seeman

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Jan Aten

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Karen Ghauharali-van der Vlugt

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Nora Bijl

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Peter F Dubbelhuis

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Roelof Ottenhoff

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P2860

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin

Obesity, Inflammation, and Insulin Resistance

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

A simple method for the isolation and purification of total lipides from animal tissues

A new mathematical model for relative quantification in real-time RT-PCR

Inflammation and metabolic disorders

Obesity is associated with macrophage accumulation in adipose tissue

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

Principles of bioactive lipid signalling: lessons from sphingolipids

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

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e4723

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10.1371/JOURNAL.PONE.0004723

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