Zinc-finger-based artificial transcription factors and their applications.
about
A mutation in ZNF513, a putative regulator of photoreceptor development, causes autosomal-recessive retinitis pigmentosaThe New State of the Art: Cas9 for Gene Activation and RepressionProtein design: toward functional metalloenzymesThe prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disordersEpCAM in carcinogenesis: the good, the bad or the uglyCysteine and histidine shuffling: mixing and matching cysteine and histidine residues in zinc finger proteins to afford different folds and function.Upregulation of endogenous HMOX1 expression by a computer-designed artificial transcription factor.Eukaryotic systems broaden the scope of synthetic biology.Local gene regulation details a recognition code within the LacI transcriptional factor family.Genetic and epigenetic control of gene expression by CRISPR-Cas systems.The prospects for designer single-stranded RNA-binding proteins.Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors.Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small moleculesUtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation.Experimental strategies for studying transcription factor-DNA binding specificities.Sequence specificity at targeting double-stranded DNA with a γ-PNA oligomer modified with guanidinium G-clamp nucleobases.The generation of zinc finger proteins by modular assembly.Targeted genome regulation via synthetic programmable transcriptional regulators.Targeted silencing of the oncogenic transcription factor SOX2 in breast cancerIdentification of Position-Specific Correlations between DNA-Binding Domains and Their Binding Sites. Application to the MerR Family of Transcription Factors.The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors.Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes.Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer.Breaking through an epigenetic wall: re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors.Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus.Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system.New approaches for modelling sporadic genetic disease in the mouseToward engineering synthetic microbial metabolism.Small-molecule regulators that mimic transcription factorsTransition metal homeostasis: from yeast to human disease.Genetically engineered light sensors for control of bacterial gene expression.Drugging the undruggable: transcription therapy for cancer.Engineered zinc-finger transcription factors activate OCT4 (POU5F1), SOX2, KLF4, c-MYC (MYC) and miR302/367.Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5'-LTR promoter.Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion.Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm.Novel adeno-associated viral vector delivering the utrophin gene regulator jazz counteracts dystrophic pathology in mdx mice.Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factorsFunctional rules for lac repressor-operator associations and implications for protein-DNA interactions.
P2860
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P2860
Zinc-finger-based artificial transcription factors and their applications.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Zinc-finger-based artificial transcription factors and their applications.
@ast
Zinc-finger-based artificial transcription factors and their applications.
@en
type
label
Zinc-finger-based artificial transcription factors and their applications.
@ast
Zinc-finger-based artificial transcription factors and their applications.
@en
prefLabel
Zinc-finger-based artificial transcription factors and their applications.
@ast
Zinc-finger-based artificial transcription factors and their applications.
@en
P1476
Zinc-finger-based artificial transcription factors and their applications.
@en
P2093
Takashi Sera
P304
P356
10.1016/J.ADDR.2009.03.012
P407
P577
2009-04-23T00:00:00Z