Antifolate activity of pyrimethamine enhances temozolomide-induced cytotoxicity in melanoma cells.

Antifolate activity of pyrimethamine enhances temozolomide-induced cytotoxicity in melanoma cells.

Item
http://www.wikidata.org/entity/Q33444426
The combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53Engineered drug-resistant immunocompetent cells enhance tumor cell killing during a chemotherapy challenge.Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibilityResveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells.Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytesFour clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screeningNew derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study.Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways.Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response.The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.
P2860

Antifolate activity of pyrimethamine enhances temozolomide-induced cytotoxicity in melanoma cells.

Item
http://www.wikidata.org/entity/Q33444426
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Antifolate activity of pyrimet ...... ytotoxicity in melanoma cells.
@ast
Antifolate activity of pyrimet ...... ytotoxicity in melanoma cells.
@en
type
label
Antifolate activity of pyrimet ...... ytotoxicity in melanoma cells.
@ast
Antifolate activity of pyrimet ...... ytotoxicity in melanoma cells.
@en
prefLabel
Antifolate activity of pyrimet ...... ytotoxicity in melanoma cells.
@ast
Antifolate activity of pyrimet ...... ytotoxicity in melanoma cells.
@en
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Antifolate activity of pyrimet ...... ytotoxicity in melanoma cells.
@en
P2093
P304
P31
P356
10.1158/1541-7786.MCR-08-0263
P433
P478
P50
P577
P698
P921