Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
about
Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levelsTetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNAEffects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabineIncreased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapyHigh cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects.Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice.Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.Fetal Hemoglobin Induction by Epigenetic Drugs
P2860
Q34195332-608D8AFC-0812-4363-A082-17CC26F9B265Q34278045-0347B0D4-CF8B-44B7-A9E8-7CC6FF398B2FQ35236445-8E785B23-8E38-4C51-8410-FEB48A512417Q35750354-23051826-5ED4-43EE-96CA-95EE5B8A5C47Q36625233-CB6586BC-FFDD-48C6-8EF9-020974F57079Q37031262-79EC1174-C296-4F0D-AE68-2B6BA2CC122AQ37180971-19EF5B63-6A5C-4F45-97BB-30B7A65488DDQ41576877-0E04FA8E-E940-479B-93BD-0941BCB4324CQ57753972-805C28C7-8766-4FCC-9CAE-3FD70D0D4A85
P2860
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
description
1979 nî lūn-bûn
@nan
1979 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1979 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
name
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
@ast
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
@en
type
label
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
@ast
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
@en
prefLabel
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
@ast
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
@en
P2093
P1476
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside.
@en
P2093
Burchenal JH
Krakoff IH
P304
P577
1979-08-01T00:00:00Z