Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.
about
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomesNramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic poolFibrates induce mdr2 gene expression and biliary phospholipid secretion in the mousemRNA levels of related Abcb genes change opposite to each other upon histone deacetylase inhibition in drug-resistant rat hepatoma cellsOntogeny of ABC and SLC transporters in the microvessels of developing rat brainP-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytesFunctional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genesP450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.Isolation and characterization of Drosophila multidrug resistance gene homologs.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Changes in the placental glucocorticoid barrier during rat pregnancy: impact on placental corticosterone levels and regulation by progesterone.Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposureFunctional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.Expression and function of multidrug resistance transporters at the blood-brain barriers.Pluronics and MDR reversal: an update.Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.Multidrug resistance genes and p-glycoprotein in the testis of the rat, mouse, Guinea pig, and human.Incorporation of ABCB1-mediated transport into a physiologically-based pharmacokinetic model of docetaxel in mice.Cloning and regulation of the rat mdr2 geneCharles F. Kettering Prize. P-glycoprotein and resistance to anticancer drugs.Mechanisms of multidrug resistance in cancer treatment.Identification of trichlormethiazide as a Mdr1a/b gene expression enhancer via a dual secretion-based promoter assay.Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings.Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesisThe multidrug resistance P-glycoprotein modulates cell regulatory volume decreaseNormal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.P-glycoprotein structure and evolutionary homologies.Human multidrug resistance 3-P-glycoprotein expression in transgenic mice induces lens membrane alterations leading to cataract.Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?ABC drug transporter at the blood-brain barrier: effects on drug metabolism and drug response.Multidrug resistance: a novel class of membrane-associated transport proteins is identified.Functional expression of mouse mdr1 in Escherichia coli.Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520.ABC transporters, neural stem cells and neurogenesis--a different perspective.Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine.Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cellsA possible role for a mammalian facilitative hexose transporter in the development of resistance to drugs
P2860
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P2860
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.
description
1990 nî lūn-bûn
@nan
1990 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Two members of the mouse mdr g ...... t distinct drug specificities.
@ast
Two members of the mouse mdr g ...... t distinct drug specificities.
@en
type
label
Two members of the mouse mdr g ...... t distinct drug specificities.
@ast
Two members of the mouse mdr g ...... t distinct drug specificities.
@en
prefLabel
Two members of the mouse mdr g ...... t distinct drug specificities.
@ast
Two members of the mouse mdr g ...... t distinct drug specificities.
@en
P2860
P356
P1476
Two members of the mouse mdr g ...... t distinct drug specificities.
@en
P2093
P2860
P304
P356
10.1128/MCB.10.4.1652
P407
P577
1990-04-01T00:00:00Z